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Intraoperative continuous insulin infusion
Intraoperative continuous insulin infusion maintains tight perioperative glycemic control by delivering insulin intravenously during surgery to prevent hyperglycemia-related complications.
Intraoperative continuous insulin infusion maintains tight perioperative glycemic control by delivering insulin intravenously during surgery to prevent hyperglycemia-related complications. Used for Perioperative glycemic control in surgical patients, particularly those undergoing cardiac surgery or major procedures.
At a glance
| Generic name | Intraoperative continuous insulin infusion |
|---|---|
| Sponsor | Rabin Medical Center |
| Drug class | Insulin (human recombinant) |
| Target | Insulin receptor |
| Modality | Small molecule |
| Therapeutic area | Perioperative care / Endocrinology |
| Phase | FDA-approved |
Mechanism of action
This is a clinical protocol rather than a novel drug entity—it involves continuous IV insulin administration during the intraoperative period to maintain blood glucose within a target range (typically 80–180 mg/dL). Tight glycemic control during surgery reduces surgical site infections, improves wound healing, and decreases postoperative morbidity by mitigating the stress hyperglycemia response and its inflammatory consequences.
Approved indications
- Perioperative glycemic control in surgical patients, particularly those undergoing cardiac surgery or major procedures
Common side effects
- Hypoglycemia
- Hypokalemia
Key clinical trials
- Intraoperative Continuous Lidocaine Infusion in Laparoscopic Liver Surgery (NA)
- Intravenous Bolus-infusion Versus Sliding Scale of Insulin for Intra-operative Glycemic Control (EARLY_PHASE1)
- Automated vs Conventional Perioperative Glycemic Control in Diabetic Patients Undergoing Cardiopulmonary Bypass Surgery (NA)
- Glycemic Stability During the Intraoperative Period Among Patients With DM Undergoing CABG Surgery (NA)
- The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose (NA)
- The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery (NA)
- Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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