{"id":"intraoperative-continuous-insulin-infusion","safety":{"commonSideEffects":[{"rate":"variable, depends on infusion protocol and monitoring","effect":"Hypoglycemia"},{"rate":"variable","effect":"Hypokalemia"}]},"_chembl":{"chemblId":"CHEMBL1201631","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a clinical protocol rather than a novel drug entity—it involves continuous IV insulin administration during the intraoperative period to maintain blood glucose within a target range (typically 80–180 mg/dL). Tight glycemic control during surgery reduces surgical site infections, improves wound healing, and decreases postoperative morbidity by mitigating the stress hyperglycemia response and its inflammatory consequences.","oneSentence":"Intraoperative continuous insulin infusion maintains tight perioperative glycemic control by delivering insulin intravenously during surgery to prevent hyperglycemia-related complications.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:38.750Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative glycemic control in surgical patients, particularly those undergoing cardiac surgery or major procedures"}]},"trialDetails":[{"nctId":"NCT07012889","phase":"NA","title":"Intraoperative Continuous Lidocaine Infusion in Laparoscopic Liver Surgery","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2025-06-01","conditions":"Postoperative Pain After Laparoscopic Liver Resection","enrollment":94},{"nctId":"NCT05136157","phase":"EARLY_PHASE1","title":"Intravenous Bolus-infusion Versus Sliding Scale of Insulin for Intra-operative Glycemic Control","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-11-01","conditions":"Intraoperative Complications","enrollment":60},{"nctId":"NCT03314272","phase":"NA","title":"Automated vs Conventional Perioperative Glycemic Control in Diabetic Patients Undergoing Cardiopulmonary Bypass Surgery","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2018-05-16","conditions":"Diabetes, Cardiopulmonary Bypass","enrollment":59},{"nctId":"NCT04451655","phase":"NA","title":"Glycemic Stability During the Intraoperative Period Among Patients With DM Undergoing CABG Surgery","status":"COMPLETED","sponsor":"Audai A. Hayajneh","startDate":"2018-09-01","conditions":"Blood Glucose","enrollment":72},{"nctId":"NCT01187329","phase":"NA","title":"The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2010-10","conditions":"Hyperglycemia, Aortic Valve Replacement, Aortic Stenosis","enrollment":100},{"nctId":"NCT01831154","phase":"NA","title":"The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery","status":"COMPLETED","sponsor":"James A. Haley Veterans Administration Hospital","startDate":"2010-05","conditions":"Diabetes, Hyperglycemia, Surgical Site Infection","enrollment":37},{"nctId":"NCT00394303","phase":"PHASE4","title":"Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery","status":"TERMINATED","sponsor":"Rabin Medical Center","startDate":"2007-02","conditions":"Coronary Artery Bypass","enrollment":1400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intraoperative continuous insulin infusion","genericName":"Intraoperative continuous insulin infusion","companyName":"Rabin Medical Center","companyId":"rabin-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intraoperative continuous insulin infusion maintains tight perioperative glycemic control by delivering insulin intravenously during surgery to prevent hyperglycemia-related complications. Used for Perioperative glycemic control in surgical patients, particularly those undergoing cardiac surgery or major procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}