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Intranasal Paracetamol
Intranasal paracetamol inhibits cyclooxygenase enzymes in the central nervous system to reduce pain and fever perception.
Intranasal paracetamol inhibits cyclooxygenase enzymes in the central nervous system to reduce pain and fever perception. Used for Acute pain management, Fever reduction.
At a glance
| Generic name | Intranasal Paracetamol |
|---|---|
| Sponsor | Bezmialem Vakif University |
| Drug class | Analgesic and antipyretic (non-NSAID) |
| Target | Cyclooxygenase (COX) enzymes |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Paracetamol (acetaminophen) is a non-selective inhibitor of cyclooxygenase (COX) enzymes, primarily acting in the brain and spinal cord to suppress prostaglandin synthesis. The intranasal formulation delivers the drug directly to nasal mucosa for rapid systemic absorption, potentially providing faster onset of analgesic and antipyretic effects compared to oral administration. This route bypasses first-pass hepatic metabolism to some degree, potentially allowing lower doses to achieve therapeutic effect.
Approved indications
- Acute pain management
- Fever reduction
Common side effects
- Nasal irritation
- Headache
- Rhinitis
- Hepatotoxicity (at high doses)
Key clinical trials
- A Non-randomised, Non-inferiority Comparative Study of Oral Actiskenan (Morphine Sulfate) Versus Intranasal Sufentanil in the Early Management of Severe Acute Pain in Emergency Departments.
- Analgesic Effects of Intranasal Diclofenac Sodium, Ibuprofen, and Paracetamol in Pediatric Tonsillectomy Cases (PHASE3)
- Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19 (PHASE2, PHASE3)
- Comparison of Postoperative Analgesia Between Intravenous Paracetamol and Intranasal Tapentadol (PHASE4)
- Sprix for Postoperative Pain Control Following Gynecologic Surgery (PHASE4)
- IN Sub-Dissociative Ketamine vs IN Fentanyl (PHASE2)
- Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group (PHASE2)
- Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intranasal Paracetamol CI brief — competitive landscape report
- Intranasal Paracetamol updates RSS · CI watch RSS
- Bezmialem Vakif University portfolio CI