{"id":"intranasal-paracetamol","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rhinitis"},{"rate":null,"effect":"Hepatotoxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) is a non-selective inhibitor of cyclooxygenase (COX) enzymes, primarily acting in the brain and spinal cord to suppress prostaglandin synthesis. The intranasal formulation delivers the drug directly to nasal mucosa for rapid systemic absorption, potentially providing faster onset of analgesic and antipyretic effects compared to oral administration. This route bypasses first-pass hepatic metabolism to some degree, potentially allowing lower doses to achieve therapeutic effect.","oneSentence":"Intranasal paracetamol inhibits cyclooxygenase enzymes in the central nervous system to reduce pain and fever perception.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:41.005Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT07344350","phase":"","title":"A Non-randomised, Non-inferiority Comparative Study of Oral Actiskenan (Morphine Sulfate) Versus Intranasal Sufentanil in the Early Management of Severe Acute Pain in Emergency Departments.","status":"NOT_YET_RECRUITING","sponsor":"Groupe Hospitalier de la Region de Mulhouse et Sud Alsace","startDate":"2026-01-31","conditions":"Severe Acute Pain","enrollment":400},{"nctId":"NCT06731556","phase":"PHASE3","title":"Analgesic Effects of Intranasal Diclofenac Sodium, Ibuprofen, and Paracetamol in Pediatric Tonsillectomy Cases","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2024-12-15","conditions":"Tonsil Disease, Pain Management, Intranasal Drug Administration","enrollment":60},{"nctId":"NCT05783206","phase":"PHASE2, PHASE3","title":"Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19","status":"COMPLETED","sponsor":"National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia","startDate":"2022-02-10","conditions":"COVID-19","enrollment":984},{"nctId":"NCT05999890","phase":"PHASE4","title":"Comparison of Postoperative Analgesia Between Intravenous Paracetamol and Intranasal Tapentadol","status":"COMPLETED","sponsor":"Kempegowda Institute of Medical Sciences, Bangalore","startDate":"2021-07-05","conditions":"Lower Limb Fracture","enrollment":74},{"nctId":"NCT04444830","phase":"PHASE4","title":"Sprix for Postoperative Pain Control Following Gynecologic Surgery","status":"WITHDRAWN","sponsor":"University of Louisville","startDate":"2021-01","conditions":"Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse","enrollment":""},{"nctId":"NCT02521415","phase":"PHASE2","title":"IN Sub-Dissociative Ketamine vs IN Fentanyl","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2015-12","conditions":"Bone Fracture","enrollment":87},{"nctId":"NCT04949477","phase":"PHASE2","title":"Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group","status":"COMPLETED","sponsor":"Benha University","startDate":"2021-07-01","conditions":"Anxiety","enrollment":86},{"nctId":"NCT02573714","phase":"NA","title":"Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises","status":"UNKNOWN","sponsor":"Cameroon Baptist Convention Health","startDate":"2015-12","conditions":"Sickle Cell Disease","enrollment":160},{"nctId":"NCT00855049","phase":"NA","title":"A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults","status":"WITHDRAWN","sponsor":"University of Texas Southwestern Medical Center","startDate":"2009-04","conditions":"Pharmacokinetics","enrollment":""},{"nctId":"NCT01759446","phase":"PHASE2","title":"Abuse Potential of Intranasal VYCAVERT Tablets (Hydrocodone Bitartrate/Acetaminophen) in Recreational Opioid Users","status":"COMPLETED","sponsor":"Acura Pharmaceuticals Inc.","startDate":"2013-02","conditions":"Opioid-Related Disorders","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intranasal Paracetamol","genericName":"Intranasal Paracetamol","companyName":"Bezmialem Vakif University","companyId":"bezmialem-vakif-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intranasal paracetamol inhibits cyclooxygenase enzymes in the central nervous system to reduce pain and fever perception. Used for Acute pain management, Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}