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Intranasal Ketorolac Tromethamine
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide rapid pain relief and anti-inflammatory effects.
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and provide rapid pain relief and anti-inflammatory effects. Used for Acute moderate to severe pain, Postoperative pain, Migraine headache.
At a glance
| Generic name | Intranasal Ketorolac Tromethamine |
|---|---|
| Also known as | Atomized Intranasal Ketorolac |
| Sponsor | Tehran University of Medical Sciences |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase (COX-1 and COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ketorolac works by blocking COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. The intranasal formulation allows for rapid systemic absorption and faster onset of action compared to oral routes, making it suitable for acute pain management. This route of administration bypasses first-pass hepatic metabolism and provides analgesic effects within minutes.
Approved indications
- Acute moderate to severe pain
- Postoperative pain
- Migraine headache
Common side effects
- Nasal irritation or discomfort
- Headache
- Nausea
- Dizziness
- Gastrointestinal upset
- Rhinitis
Key clinical trials
- Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain (PHASE3)
- Sprix for Postoperative Pain Control Following Gynecologic Surgery (PHASE4)
- Atomized Intranasal Vs Intravenous Ketorolac in Acute Renal Colic Pain Management. (PHASE2, PHASE3)
- Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children (PHASE3)
- Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children (PHASE4)
- Pharmacokinetics of Intranasal Ketorolac in Children (PHASE1)
- Study to Assess the Absorption and Tolerability of Intranasal Ketorolac Tromethamine and to Assess the Effects of Oxymetazoline Hydrochloride and Fluticasone Propionate on the Absorption and Tolerability of Intranasal Ketorolac Tromethamine in Participants With Allergic Rhinitis (PHASE1)
- Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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