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intralesional vitamin D3
Intralesional vitamin D3 activates vitamin D receptors in skin lesions to promote differentiation and apoptosis of abnormal keratinocytes and modulate local immune responses.
Intralesional vitamin D3 activates vitamin D receptors in skin lesions to promote differentiation and apoptosis of abnormal keratinocytes and modulate local immune responses. Used for Psoriasis (intralesional injection), Vitiligo (intralesional injection).
At a glance
| Generic name | intralesional vitamin D3 |
|---|---|
| Sponsor | Combined Military Hospital Abbottabad |
| Drug class | Vitamin D analog / immunomodulator |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Vitamin D3 (cholecalciferol) binds to the vitamin D receptor (VDR) in target tissues, triggering transcriptional changes that promote keratinocyte differentiation, reduce proliferation, and enhance local immunoregulation. When injected directly into lesions, it exerts anti-inflammatory and anti-proliferative effects on dermatological conditions. This local delivery approach concentrates the therapeutic effect at the disease site while minimizing systemic exposure.
Approved indications
- Psoriasis (intralesional injection)
- Vitiligo (intralesional injection)
Common side effects
- Local injection site irritation
- Hypercalcemia (with systemic absorption)
- Local erythema or edema
Key clinical trials
- Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir (PHASE4)
- Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata (PHASE4)
- Intralesional Vitamin D Versus Intralesional Acyclovir in Plantar Warts (PHASE4)
- Effect of Vitamin D Injection on Hypertrophic Scars and Keloids (PHASE1, PHASE2)
- Intralesional Treatment of Keloids (PHASE3)
- Intralesional Vitamin D Injection for Treatment of Common Warts (PHASE2)
- Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts (PHASE1)
- Intralesional Vitamin D3 Versus Intralesional Acyclovir in Treatment of Plantar Warts (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |