{"id":"intralesional-vitamin-d3","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site irritation"},{"rate":null,"effect":"Hypercalcemia (with systemic absorption)"},{"rate":null,"effect":"Local erythema or edema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin D3 (cholecalciferol) binds to the vitamin D receptor (VDR) in target tissues, triggering transcriptional changes that promote keratinocyte differentiation, reduce proliferation, and enhance local immunoregulation. When injected directly into lesions, it exerts anti-inflammatory and anti-proliferative effects on dermatological conditions. This local delivery approach concentrates the therapeutic effect at the disease site while minimizing systemic exposure.","oneSentence":"Intralesional vitamin D3 activates vitamin D receptors in skin lesions to promote differentiation and apoptosis of abnormal keratinocytes and modulate local immune responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:49:33.743Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis (intralesional injection)"},{"name":"Vitiligo (intralesional injection)"}]},"trialDetails":[{"nctId":"NCT07448844","phase":"PHASE4","title":"Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir","status":"RECRUITING","sponsor":"Riphah International University","startDate":"2026-02-20","conditions":"Viral Wart, Plantar Wart, Common Warts (Verruca Vulgaris)","enrollment":40},{"nctId":"NCT07453238","phase":"PHASE4","title":"Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata","status":"NOT_YET_RECRUITING","sponsor":"Hayat Abad Medical Complex, Peshawar","startDate":"2026-04-01","conditions":"Alopecia Areata","enrollment":60},{"nctId":"NCT07196670","phase":"PHASE4","title":"Intralesional Vitamin D Versus Intralesional Acyclovir in Plantar Warts","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-09","conditions":"Plantar Warts Treatment","enrollment":60},{"nctId":"NCT06301178","phase":"PHASE1, PHASE2","title":"Effect of Vitamin D Injection on Hypertrophic Scars and Keloids","status":"COMPLETED","sponsor":"Mostafa Bahaa","startDate":"2024-02-27","conditions":"Dermatologic Disease","enrollment":35},{"nctId":"NCT06729840","phase":"PHASE3","title":"Intralesional Treatment of Keloids","status":"RECRUITING","sponsor":"Sohag University","startDate":"2024-12-01","conditions":"Scar, Hypertrophic","enrollment":45},{"nctId":"NCT04278573","phase":"PHASE2","title":"Intralesional Vitamin D Injection for Treatment of Common Warts","status":"COMPLETED","sponsor":"Stephen P. Merry","startDate":"2020-10-20","conditions":"Warts","enrollment":77},{"nctId":"NCT05739786","phase":"PHASE1","title":"Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-05-11","conditions":"Cutaneous Warts","enrollment":60},{"nctId":"NCT05324904","phase":"NA","title":"Intralesional Vitamin D3 Versus Intralesional Acyclovir in Treatment of Plantar Warts","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-10","conditions":"Plantar Wart","enrollment":44},{"nctId":"NCT04660786","phase":"PHASE1, PHASE2","title":"Intralesional Vitamin D in Alopecia Areata","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2021-11-01","conditions":"Alopecia Areata","enrollment":40},{"nctId":"NCT04428359","phase":"NA","title":"A Comparative Study to Assess Efficacy of Intralesional MMR Vaccine and Intralesional Vitamin D3 in Treatment of Warts","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2020-06-01","conditions":"Verruca Viral","enrollment":66}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":39,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"intralesional vitamin D3","genericName":"intralesional vitamin D3","companyName":"Combined Military Hospital Abbottabad","companyId":"combined-military-hospital-abbottabad","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intralesional vitamin D3 is a treatment option studied for various conditions, including plantar warts, alopecia areata, and hypertrophic scars, with a randomized clinical trial comparing its efficacy to intralesional acyclovir in treating plantar warts. As a small molecule vitamin D receptor agonist, intralesional vitamin D3 works by activating the vitamin D receptor.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}