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Intralesional Steroid Injection
Intralesional Steroid Injection is a Corticosteroid Small molecule drug developed by Services Institute of Medical Sciences, Pakistan. It is currently FDA-approved for Keloids and hypertrophic scars, Lichen planus, Alopecia areata.
Intralesional steroid injection delivers corticosteroids directly into a localized lesion to suppress local inflammation and immune response.
Intralesional steroid injection delivers corticosteroids directly into a localized lesion to suppress local inflammation and immune response. Used for Keloids and hypertrophic scars, Lichen planus, Alopecia areata.
At a glance
| Generic name | Intralesional Steroid Injection |
|---|---|
| Sponsor | Services Institute of Medical Sciences, Pakistan |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Corticosteroids work by binding to glucocorticoid receptors in immune cells, suppressing pro-inflammatory cytokine production and reducing local inflammation, edema, and immune cell infiltration. Direct injection into the lesion achieves high local drug concentration while minimizing systemic exposure and side effects.
Approved indications
- Keloids and hypertrophic scars
- Lichen planus
- Alopecia areata
- Psoriasis plaques
- Lichen sclerosus
- Localized inflammatory skin lesions
Common side effects
- Local skin atrophy
- Telangiectasia (dilated blood vessels)
- Hypopigmentation or hyperpigmentation
- Local pain or burning at injection site
- Systemic steroid absorption (minimal with intralesional route)
Key clinical trials
- Local Methotrexate Injections for the Treatment of Nail Psoriasis (PHASE4)
- Use of Steroid Injections to Prevent the Recurrence of Tracheal Stenosis in Idiopathic Subglottic Stenosis (PHASE3)
- Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata (PHASE4)
- Topical Cryotherapy and Keloid/Hypertrophic Scars (PHASE3)
- Comparison of Intralesional Triamcinolone Acetonide Treatment With Intralesional Verapamil Hydrochloride in Keloids (NA)
- Intralesional Steroid Injection Versus Voice Therapy in Management of Vocal Nodules (PHASE4)
- Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial. (PHASE3)
- Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous Fibrosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intralesional Steroid Injection CI brief — competitive landscape report
- Intralesional Steroid Injection updates RSS · CI watch RSS
- Services Institute of Medical Sciences, Pakistan portfolio CI
Frequently asked questions about Intralesional Steroid Injection
What is Intralesional Steroid Injection?
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Related
- Drug class: All Corticosteroid drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: Services Institute of Medical Sciences, Pakistan — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Keloids and hypertrophic scars
- Indication: Drugs for Lichen planus
- Indication: Drugs for Alopecia areata
- Compare: Intralesional Steroid Injection vs similar drugs
- Pricing: Intralesional Steroid Injection cost, discount & access