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Intra-articular Compound Betamethasone
Betamethasone is a corticosteroid that suppresses local inflammatory and immune responses when injected directly into a joint.
Betamethasone is a corticosteroid that suppresses local inflammatory and immune responses when injected directly into a joint. Used for Intra-articular inflammation and pain in rheumatoid arthritis, Osteoarthritis joint inflammation, Other inflammatory joint conditions.
At a glance
| Generic name | Intra-articular Compound Betamethasone |
|---|---|
| Sponsor | Chinese PLA General Hospital |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Betamethasone binds to glucocorticoid receptors in synovial tissue and immune cells, reducing production of pro-inflammatory cytokines, inhibiting leukocyte infiltration, and decreasing synovial inflammation. Intra-articular administration delivers the drug locally to the affected joint, minimizing systemic exposure while providing anti-inflammatory and immunosuppressive effects that reduce pain and swelling.
Approved indications
- Intra-articular inflammation and pain in rheumatoid arthritis
- Osteoarthritis joint inflammation
- Other inflammatory joint conditions
Common side effects
- Local joint pain or swelling post-injection
- Transient increase in joint symptoms
- Infection at injection site
- Systemic corticosteroid effects (with repeated injections)
Key clinical trials
- Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder (PHASE4)
- Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuff Injury With Shoulder Adhesion: A Prospective, Multicenter, Randomized Controlled Trial (NA)
- Radiofrequency Ablation in the Pain Management of Knee Osteoarthritis (NA)
- The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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