{"id":"intra-articular-compound-betamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Local joint pain or swelling post-injection"},{"rate":null,"effect":"Transient increase in joint symptoms"},{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Systemic corticosteroid effects (with repeated injections)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Betamethasone binds to glucocorticoid receptors in synovial tissue and immune cells, reducing production of pro-inflammatory cytokines, inhibiting leukocyte infiltration, and decreasing synovial inflammation. Intra-articular administration delivers the drug locally to the affected joint, minimizing systemic exposure while providing anti-inflammatory and immunosuppressive effects that reduce pain and swelling.","oneSentence":"Betamethasone is a corticosteroid that suppresses local inflammatory and immune responses when injected directly into a joint.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:29.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intra-articular inflammation and pain in rheumatoid arthritis"},{"name":"Osteoarthritis joint inflammation"},{"name":"Other inflammatory joint conditions"}]},"trialDetails":[{"nctId":"NCT07416916","phase":"PHASE4","title":"Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-02-23","conditions":"Frozen Shoulder","enrollment":528},{"nctId":"NCT07348016","phase":"NA","title":"Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuff Injury With Shoulder Adhesion: A Prospective, Multicenter, Randomized Controlled Trial","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2025-08-01","conditions":"Rotator Cuff Injuries, Adhesions","enrollment":70},{"nctId":"NCT05303766","phase":"NA","title":"Radiofrequency Ablation in the Pain Management of Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-04","conditions":"Knee Osteoarthritis","enrollment":150},{"nctId":"NCT03215407","phase":"PHASE4","title":"The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone","status":"UNKNOWN","sponsor":"Chinese PLA General Hospital","startDate":"2017-08-01","conditions":"Rheumatoid Arthritis of Knee","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intra-articular Compound Betamethasone","genericName":"Intra-articular Compound Betamethasone","companyName":"Chinese PLA General Hospital","companyId":"chinese-pla-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Betamethasone is a corticosteroid that suppresses local inflammatory and immune responses when injected directly into a joint. Used for Intra-articular inflammation and pain in rheumatoid arthritis, Osteoarthritis joint inflammation, Other inflammatory joint conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}