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Intermittent OC (EE/DROS)
Intermittent OC (EE/DROS) is an oral contraceptive containing ethinyl estradiol and drospirenone that prevents pregnancy through hormonal suppression of ovulation.
Intermittent OC (EE/DROS) is an oral contraceptive containing ethinyl estradiol and drospirenone that prevents pregnancy through hormonal suppression of ovulation. Used for Contraception in women of reproductive age.
At a glance
| Generic name | Intermittent OC (EE/DROS) |
|---|---|
| Also known as | Yaz |
| Sponsor | University of North Carolina, Chapel Hill |
| Drug class | Oral contraceptive |
| Target | Progesterone receptor, estrogen receptor |
| Modality | Small molecule |
| Therapeutic area | Contraception |
| Phase | FDA-approved |
Mechanism of action
This combination oral contraceptive delivers ethinyl estradiol (a synthetic estrogen) and drospirenone (a progestin with antimineralocorticoid activity) in an intermittent dosing regimen. The hormones work synergistically to inhibit the LH surge required for ovulation, thicken cervical mucus to impede sperm transport, and alter the endometrium to prevent implantation. The intermittent dosing pattern may reduce hormone exposure while maintaining contraceptive efficacy.
Approved indications
- Contraception in women of reproductive age
Common side effects
- Nausea
- Headache
- Breast tenderness
- Breakthrough bleeding
- Mood changes
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |