{"id":"intermittent-oc-ee-dros","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Breakthrough bleeding"},{"rate":null,"effect":"Mood changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination oral contraceptive delivers ethinyl estradiol (a synthetic estrogen) and drospirenone (a progestin with antimineralocorticoid activity) in an intermittent dosing regimen. The hormones work synergistically to inhibit the LH surge required for ovulation, thicken cervical mucus to impede sperm transport, and alter the endometrium to prevent implantation. The intermittent dosing pattern may reduce hormone exposure while maintaining contraceptive efficacy.","oneSentence":"Intermittent OC (EE/DROS) is an oral contraceptive containing ethinyl estradiol and drospirenone that prevents pregnancy through hormonal suppression of ovulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:26.757Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT00927095","phase":"PHASE4","title":"Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2008-07","conditions":"Premenstrual Dysphoric Disorder","enrollment":67}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Yaz"],"phase":"marketed","status":"active","brandName":"Intermittent OC (EE/DROS)","genericName":"Intermittent OC (EE/DROS)","companyName":"University of North Carolina, Chapel Hill","companyId":"university-of-north-carolina-chapel-hill","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intermittent OC (EE/DROS) is an oral contraceptive containing ethinyl estradiol and drospirenone that prevents pregnancy through hormonal suppression of ovulation. Used for Contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}