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Inhaled isopropyl alcohol
Inhaled isopropyl alcohol vapor acts as a rapid-onset antiemetic by stimulating olfactory and trigeminal nerve pathways, reducing nausea signals to the brain.
Inhaled isopropyl alcohol vapor acts as a rapid-onset antiemetic by stimulating olfactory and trigeminal nerve pathways, reducing nausea signals to the brain. Used for Nausea and vomiting in acute care and perioperative settings.
At a glance
| Generic name | Inhaled isopropyl alcohol |
|---|---|
| Also known as | ISO |
| Sponsor | Brooke Army Medical Center |
| Drug class | Aromatic inhalant antiemetic |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Acute Care |
| Phase | FDA-approved |
Mechanism of action
Isopropyl alcohol inhalation is believed to work through aromatic inhalation and direct stimulation of nasal sensory receptors, particularly the trigeminal nerve, which modulates nausea and vomiting centers in the brainstem. The mechanism is distinct from systemic antiemetics and provides rapid symptom relief, typically within minutes of inhalation. This approach is particularly useful in acute care settings where rapid nausea relief is needed.
Approved indications
- Nausea and vomiting in acute care and perioperative settings
Common side effects
- Local airway irritation
- Transient headache
- Dizziness
Key clinical trials
- Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer (PHASE2)
- Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine (NA)
- Inhaled Isopropyl Alcohol for Treatment of Nausea (PHASE2, PHASE3)
- Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals (NA)
- Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED) (EARLY_PHASE1)
- Isopropyl Alcohol Inhalation as Anti-emetic Therapy in the Emergency Department (NA)
- Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department (PHASE4)
- Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Inhaled isopropyl alcohol CI brief — competitive landscape report
- Inhaled isopropyl alcohol updates RSS · CI watch RSS
- Brooke Army Medical Center portfolio CI