{"id":"inhaled-isopropyl-alcohol","safety":{"commonSideEffects":[{"rate":null,"effect":"Local airway irritation"},{"rate":null,"effect":"Transient headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isopropyl alcohol inhalation is believed to work through aromatic inhalation and direct stimulation of nasal sensory receptors, particularly the trigeminal nerve, which modulates nausea and vomiting centers in the brainstem. The mechanism is distinct from systemic antiemetics and provides rapid symptom relief, typically within minutes of inhalation. This approach is particularly useful in acute care settings where rapid nausea relief is needed.","oneSentence":"Inhaled isopropyl alcohol vapor acts as a rapid-onset antiemetic by stimulating olfactory and trigeminal nerve pathways, reducing nausea signals to the brain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:55.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nausea and vomiting in acute care and perioperative settings"}]},"trialDetails":[{"nctId":"NCT04181463","phase":"PHASE2","title":"Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer","status":"NOT_YET_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-11-05","conditions":"Malignant Neoplasm","enrollment":112},{"nctId":"NCT05175521","phase":"NA","title":"Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine","status":"ACTIVE_NOT_RECRUITING","sponsor":"HonorHealth Research Institute","startDate":"2021-11-11","conditions":"Migraine","enrollment":50},{"nctId":"NCT05418244","phase":"PHASE2, PHASE3","title":"Inhaled Isopropyl Alcohol for Treatment of Nausea","status":"RECRUITING","sponsor":"State University of New York at Buffalo","startDate":"2022-04-20","conditions":"Vomiting, Nausea, Children, Only","enrollment":84},{"nctId":"NCT04307550","phase":"NA","title":"Inhaled Isopropyl Alcohol Versus Placebo to Manage Nausea at Electronic Dance Music Festivals","status":"COMPLETED","sponsor":"Anthony Seto","startDate":"2021-07-12","conditions":"Nausea","enrollment":55},{"nctId":"NCT03125811","phase":"EARLY_PHASE1","title":"Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)","status":"COMPLETED","sponsor":"Texas Tech University Health Sciences Center, El Paso","startDate":"2017-07-17","conditions":"Nausea, Vomiting","enrollment":121},{"nctId":"NCT04464915","phase":"NA","title":"Isopropyl Alcohol Inhalation as Anti-emetic Therapy in the Emergency Department","status":"WITHDRAWN","sponsor":"Ottawa Hospital Research Institute","startDate":"2020-07","conditions":"Nausea, Vomiting","enrollment":""},{"nctId":"NCT02760069","phase":"PHASE4","title":"Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department","status":"COMPLETED","sponsor":"Brooke Army Medical Center","startDate":"2016-01","conditions":"Nausea","enrollment":122},{"nctId":"NCT04403191","phase":"","title":"Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy","status":"COMPLETED","sponsor":"King Abdul Aziz Specialist Hospital","startDate":"2019-03-10","conditions":"to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs","enrollment":240},{"nctId":"NCT02092441","phase":"NA","title":"Inhalation Intervention for Nausea in the Emergency Department","status":"COMPLETED","sponsor":"Brooke Army Medical Center","startDate":"2014-04","conditions":"Nausea, Vomiting","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ISO"],"phase":"marketed","status":"active","brandName":"Inhaled isopropyl alcohol","genericName":"Inhaled isopropyl alcohol","companyName":"Brooke Army Medical Center","companyId":"brooke-army-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Inhaled isopropyl alcohol vapor acts as a rapid-onset antiemetic by stimulating olfactory and trigeminal nerve pathways, reducing nausea signals to the brain. Used for Nausea and vomiting in acute care and perioperative settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}