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INH, Rifampicin, Ethambutol and Pyrazinamide
INH, Rifampicin, Ethambutol and Pyrazinamide is a Anti-tuberculosis combination therapy Small molecule drug developed by All India Institute of Medical Sciences. It is currently in Phase 3 development for Tuberculosis (drug-susceptible pulmonary and extrapulmonary). Also known as: Category I DOTS.
This is a fixed-dose combination of four first-line anti-tuberculosis drugs that work synergistically to inhibit bacterial cell wall synthesis and mycolic acid production, killing Mycobacterium tuberculosis.
This is a fixed-dose combination of four first-line anti-tuberculosis drugs that work synergistically to inhibit bacterial cell wall synthesis and mycolic acid production, killing Mycobacterium tuberculosis. Used for Tuberculosis (drug-susceptible pulmonary and extrapulmonary).
At a glance
| Generic name | INH, Rifampicin, Ethambutol and Pyrazinamide |
|---|---|
| Also known as | Category I DOTS |
| Sponsor | All India Institute of Medical Sciences |
| Drug class | Anti-tuberculosis combination therapy |
| Target | Multiple: mycolic acid synthesis (INH), bacterial RNA polymerase (Rifampicin), arabinosyl transferases (Ethambutol), bacterial energy metabolism (Pyrazinamide) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
INH (isoniazid) inhibits mycolic acid synthesis; Rifampicin inhibits bacterial RNA polymerase; Ethambutol inhibits arabinosyl transferases in cell wall synthesis; and Pyrazinamide is converted to pyrazinoic acid which disrupts bacterial energy metabolism. Together, these agents target multiple pathways to prevent resistance and achieve rapid bactericidal activity against tuberculosis.
Approved indications
- Tuberculosis (drug-susceptible pulmonary and extrapulmonary)
Common side effects
- Hepatotoxicity
- Peripheral neuropathy (INH-related)
- Hyperuricemia (Pyrazinamide-related)
- Optic neuritis (Ethambutol-related)
- Gastrointestinal disturbance
- Rash
Key clinical trials
- Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (PHASE2)
- Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (PHASE2)
- AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT (PHASE2)
- Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis (PHASE2)
- Digitally Facilitated, Integrated Community and Facility-Based Interventions: The HEART-TB Trial Protocol (NA)
- Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB (PHASE2)
- Asymptomatic TB With Innovative Modified Short-course Regimens (PHASE4)
- ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- INH, Rifampicin, Ethambutol and Pyrazinamide CI brief — competitive landscape report
- INH, Rifampicin, Ethambutol and Pyrazinamide updates RSS · CI watch RSS
- All India Institute of Medical Sciences portfolio CI
Frequently asked questions about INH, Rifampicin, Ethambutol and Pyrazinamide
What is INH, Rifampicin, Ethambutol and Pyrazinamide?
How does INH, Rifampicin, Ethambutol and Pyrazinamide work?
What is INH, Rifampicin, Ethambutol and Pyrazinamide used for?
Who makes INH, Rifampicin, Ethambutol and Pyrazinamide?
Is INH, Rifampicin, Ethambutol and Pyrazinamide also known as anything else?
What drug class is INH, Rifampicin, Ethambutol and Pyrazinamide in?
What development phase is INH, Rifampicin, Ethambutol and Pyrazinamide in?
What are the side effects of INH, Rifampicin, Ethambutol and Pyrazinamide?
What does INH, Rifampicin, Ethambutol and Pyrazinamide target?
Related
- Drug class: All Anti-tuberculosis combination therapy drugs
- Target: All drugs targeting Multiple: mycolic acid synthesis (INH), bacterial RNA polymerase (Rifampicin), arabinosyl transferases (Ethambutol), bacterial energy metabolism (Pyrazinamide)
- Manufacturer: All India Institute of Medical Sciences — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Tuberculosis (drug-susceptible pulmonary and extrapulmonary)
- Also known as: Category I DOTS
- Compare: INH, Rifampicin, Ethambutol and Pyrazinamide vs similar drugs
- Pricing: INH, Rifampicin, Ethambutol and Pyrazinamide cost, discount & access