Last reviewed 2026-04-23 · How we verify

IDP-123 Lotion

IDP-123 is a topical lotion formulation designed to treat inflammatory skin conditions by modulating local immune and inflammatory pathways.

IDP-123 is a topical lotion formulation designed to treat inflammatory skin conditions by modulating local immune and inflammatory pathways. Used for Inflammatory skin conditions (specific indication pending Phase 3 completion).

At a glance

Mechanism of action

IDP-123 lotion is a dermatological formulation in Phase 3 development by Bausch Health. While the precise molecular mechanism has not been widely disclosed in public literature, topical formulations for inflammatory skin diseases typically work by reducing local inflammation, modulating immune cell activity, or restoring skin barrier function. The specific active ingredient and mechanism require confirmation from clinical trial data.

Approved indications

• Inflammatory skin conditions (specific indication pending Phase 3 completion)

Common side effects

No common side effects on file.

Key clinical trials

• A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301) (PHASE3)
• A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302) (PHASE3)
• Safety and Efficacy of IDP-123 Lotion to Tazorac® Cream, in the Treatment of Acne Vulgaris (PHASE2)
• Absorption and Systematic Pharmacokinetics of IDP-123 Lotion in Comparison With Tazorac Cream (PHASE1)
• Study to Compare the Safety and Efficacy of IDP-123 Lotion to Tazorac Cream in the Treatment of Acne Vulgaris (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.