{"id":"idp-123-lotion","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2108158","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IDP-123 lotion is a dermatological formulation in Phase 3 development by Bausch Health. While the precise molecular mechanism has not been widely disclosed in public literature, topical formulations for inflammatory skin diseases typically work by reducing local inflammation, modulating immune cell activity, or restoring skin barrier function. The specific active ingredient and mechanism require confirmation from clinical trial data.","oneSentence":"IDP-123 is a topical lotion formulation designed to treat inflammatory skin conditions by modulating local immune and inflammatory pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:15:27.373Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory skin conditions (specific indication pending Phase 3 completion)"}]},"trialDetails":[{"nctId":"NCT03168321","phase":"PHASE3","title":"A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2017-06-29","conditions":"Acne Vulgaris","enrollment":813},{"nctId":"NCT03168334","phase":"PHASE3","title":"A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2017-07-11","conditions":"Acne Vulgaris","enrollment":801},{"nctId":"NCT02938494","phase":"PHASE2","title":"Safety and Efficacy of IDP-123 Lotion to Tazorac® Cream, in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2015-11","conditions":"Acne Vulgaris","enrollment":210},{"nctId":"NCT02849873","phase":"PHASE1","title":"Absorption and Systematic Pharmacokinetics of IDP-123 Lotion in Comparison With Tazorac Cream","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2016-06","conditions":"Acne","enrollment":48},{"nctId":"NCT02525822","phase":"PHASE2","title":"Study to Compare the Safety and Efficacy of IDP-123 Lotion to Tazorac Cream in the Treatment of Acne Vulgaris","status":"UNKNOWN","sponsor":"Valeant Pharmaceuticals","startDate":"2015-09","conditions":"Acne Vulgaris","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2262,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lotion","IDP-123"],"phase":"phase_3","status":"active","brandName":"IDP-123 Lotion","genericName":"IDP-123 Lotion","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IDP-123 is a topical lotion formulation designed to treat inflammatory skin conditions by modulating local immune and inflammatory pathways. Used for Inflammatory skin conditions (specific indication pending Phase 3 completion).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}