Last reviewed · How we verify
Zydelig
Zydelig is a Small molecule drug developed by University of Maryland, Baltimore. It is currently FDA-approved for Chronic lymphoid leukemia, disease, Follicular non-Hodgkin's lymphoma, Malignant lymphoma - small lymphocytic. Also known as: Idelalisib.
At a glance
| Generic name | Zydelig |
|---|---|
| Also known as | Idelalisib |
| Sponsor | University of Maryland, Baltimore |
| Target | DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Approved indications
- Chronic lymphoid leukemia, disease
- Follicular non-Hodgkin's lymphoma
- Malignant lymphoma - small lymphocytic
Common side effects
- Diarrhea
- Pneumonia
- Pyrexia
- Fatigue
- Rash
- Cough
- Nausea
- Neutropenia
- ALT elevations
- AST elevations
Serious adverse events
- Pneumonia
- Diarrhea
- Pyrexia
- Sepsis
- Febrile neutropenia
- Hepatotoxicity
- Colitis
Key clinical trials
- A Study of DZD8586 Versus Investigator's Choice in r/r CLL/SLL (TAI-SHAN6) (PHASE3)
- A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (PHASE4)
- A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors (PHASE3)
- A Study of Idelalisib (GS1101, CAL101) + Ofatumumab in Previously Untreated CLL/SLL (PHASE2)
- A Phase 2 Study of CAL101 in Patients With Idiopathic Pulmonary Fibrosis (PHASE2)
- A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL (PHASE3)
- A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL (PHASE1, PHASE2)
- ACY-1215 in Combination With BCR Pathway Inhibitors in Relapsed CLL (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Zydelig CI brief — competitive landscape report
- Zydelig updates RSS · CI watch RSS
- University of Maryland, Baltimore portfolio CI
Frequently asked questions about Zydelig
What is Zydelig?
Zydelig is a Small molecule drug developed by University of Maryland, Baltimore, indicated for Chronic lymphoid leukemia, disease, Follicular non-Hodgkin's lymphoma, Malignant lymphoma - small lymphocytic.
What is Zydelig used for?
Zydelig is indicated for Chronic lymphoid leukemia, disease, Follicular non-Hodgkin's lymphoma, Malignant lymphoma - small lymphocytic.
Who makes Zydelig?
Zydelig is developed and marketed by University of Maryland, Baltimore (see full University of Maryland, Baltimore pipeline at /company/university-of-maryland-baltimore).
Is Zydelig also known as anything else?
Zydelig is also known as Idelalisib.
What development phase is Zydelig in?
Zydelig is FDA-approved (marketed).
What are the side effects of Zydelig?
Common side effects of Zydelig include Diarrhea, Pneumonia, Pyrexia, Fatigue, Rash, Cough. Serious adverse events: Pneumonia, Diarrhea, Pyrexia, Sepsis.
What does Zydelig target?
Zydelig targets DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform.
Related
- Target: All drugs targeting DNA-dependent protein kinase catalytic subunit, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
- Manufacturer: University of Maryland, Baltimore — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Chronic lymphoid leukemia, disease
- Indication: Drugs for Follicular non-Hodgkin's lymphoma
- Indication: Drugs for Malignant lymphoma - small lymphocytic
- Also known as: Idelalisib