Last reviewed 2026-04-19 · How we verify

Chronic lymphoid leukemia, disease

Approved treatments

• Valchlor · Recordati
  Valchlor works by attaching an alkyl group to the DNA of cancer cells, interfering with their ability to replicate and ultimately leading to cell death.
• Imbruvica · AbbVie
  Imbruvica works by blocking the activity of a specific enzyme called Bruton's tyrosine kinase (BTK), which is involved in the growth and survival of cancer cells.
• Arzerra · Glaxo Grp Ltd
  Arzerra works by binding to the CD20 protein on B cells, marking them for destruction by the immune system.
• Mabthera · Roche
• Fludara · Nihon Schering K.K.
  Fludara works by interfering with the production of DNA and RNA in cancer cells, ultimately leading to cell death.
• Treanda · Baxter
  Treanda works by attaching an alkyl group to the DNA of cancer cells, interfering with their ability to replicate and grow.
• Cyclophosphamid · Zhejiang University
• prednison · Wen Zhang
• Uramustin
• Imbruvica · Rabin Medical Center
• Deltasone · Generic (originally Schering)
• Leukeran · Waylis
  Leukeran works by attaching an alkyl group to the DNA of cancer cells, interfering with their ability to replicate and ultimately leading to cell death.
• Cytoxan (Lyophilized) · Baxter
  Cyclophosphamide cross-links tumor cell DNA and interferes with malignant cell growth through active alkylating metabolites.
• Venclexta · AbbVie
  Venclexta is a selective and orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein.
• Brukinsa · Beigene Usa Inc
  Brukinsa blocks the BTK protein, which is involved in the activation of B cells.
• Mabthera · Roche
  Monoclonal antibody targeting CD20 on B-lymphocytes, mediating cell lysis via CDC and ADCC.
• Mabthera · Roche
  Mabthera works by binding to the CD20 antigen on B-lymphocytes, triggering their destruction.
• Gazyva · Roche
  Gazyva binds to the CD20 antigen on B-lymphocytes, triggering their destruction.
• Cytoxan (Lyophilized) · Baxter
  Cytoxan works by interfering with the DNA replication process in rapidly dividing cancer cells.
• Copiktra · Secura
  Copiktra works by blocking an enzyme that helps cancer cells grow and multiply.
• Fludarabin · Azienda Ospedaliera San Giovanni Battista
• Bendamustin · Meir Medical Center
• Fludara · Celyad Oncology SA
• Gazyvaro · Incyte Corporation
• Arzerra · GlaxoSmithKline
• Zydelig · University of Maryland, Baltimore

Clinical guidelines

• FDA label — 1L
  VENCLEXTA is indicated for the treatment of adult patients with chronic lymphocytic leukemia (CLL).
• FDA label — 1L
  VENCLEXTA is indicated for the treatment of adult patients with small lymphocytic lymphoma (SLL).

Competitive intelligence

For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:

• Chronic lymphoid leukemia, disease patent landscape — cliff calendar, originator estates, attackable patents
• Chronic lymphoid leukemia, disease treatment landscape brief
• Chronic lymphoid leukemia, disease treatment updates RSS

Frequently asked questions about Chronic lymphoid leukemia, disease

Related

• Treatment landscape: Chronic lymphoid leukemia, disease patent cliff · Chronic lymphoid leukemia, disease CI report
• Treatment: Valchlor · Recordati
• Treatment: Imbruvica · AbbVie
• Treatment: Arzerra · Glaxo Grp Ltd
• Treatment: Mabthera · Roche
• Treatment: Fludara · Nihon Schering K.K.
• All diseases: Browse the disease index · Disease landscape hub

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing