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ICG-guided bowel perfusion assessment
ICG (indocyanine green) fluorescence imaging enables real-time visualization of bowel perfusion during surgery to assess tissue viability and prevent anastomotic complications.
ICG (indocyanine green) fluorescence imaging enables real-time visualization of bowel perfusion during surgery to assess tissue viability and prevent anastomotic complications. Used for Intraoperative assessment of bowel perfusion during colorectal surgery, Prevention of anastomotic complications in gastrointestinal surgery.
At a glance
| Generic name | ICG-guided bowel perfusion assessment |
|---|---|
| Sponsor | Leiden University Medical Center |
| Drug class | Surgical imaging agent |
| Modality | Small molecule |
| Therapeutic area | Surgery / Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
ICG is a near-infrared fluorescent dye that binds to plasma proteins and is rapidly taken up by well-perfused tissue. When excited by near-infrared light, it emits fluorescence that can be detected intraoperatively, allowing surgeons to visualize blood flow in bowel segments in real-time. This helps identify areas of compromised perfusion that may be at risk for anastomotic leak or other ischemic complications.
Approved indications
- Intraoperative assessment of bowel perfusion during colorectal surgery
- Prevention of anastomotic complications in gastrointestinal surgery
Common side effects
- Allergic reaction to ICG
- Iodine sensitivity reactions
Key clinical trials
- The Use of Indocyanine Green Near-infrared Fluorescence for Bowel Perfusion Quantitative Assessment in Order to Prevent Anastomotic Leakage in Colorectal Surgery (PHASE3)
- FLuorescence Guided Assessment of Mesenteric Ischemia in Emergency Surgery (NA)
- Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates (NA)
- Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates (PHASE3)
- Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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