{"id":"icg-guided-bowel-perfusion-assessment","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction to ICG"},{"rate":null,"effect":"Iodine sensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ICG is a near-infrared fluorescent dye that binds to plasma proteins and is rapidly taken up by well-perfused tissue. When excited by near-infrared light, it emits fluorescence that can be detected intraoperatively, allowing surgeons to visualize blood flow in bowel segments in real-time. This helps identify areas of compromised perfusion that may be at risk for anastomotic leak or other ischemic complications.","oneSentence":"ICG (indocyanine green) fluorescence imaging enables real-time visualization of bowel perfusion during surgery to assess tissue viability and prevent anastomotic complications.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:32.765Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative assessment of bowel perfusion during colorectal surgery"},{"name":"Prevention of anastomotic complications in gastrointestinal surgery"}]},"trialDetails":[{"nctId":"NCT06845306","phase":"PHASE3","title":"The Use of Indocyanine Green Near-infrared Fluorescence for Bowel Perfusion Quantitative Assessment in Order to Prevent Anastomotic Leakage in Colorectal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Vadim Kuznetsov","startDate":"2025-06-01","conditions":"Colo-rectal Cancer, Colonic Neoplasms Malignant","enrollment":1268},{"nctId":"NCT06322862","phase":"NA","title":"FLuorescence Guided Assessment of Mesenteric Ischemia in Emergency Surgery","status":"RECRUITING","sponsor":"Rigshospitalet, Denmark","startDate":"2024-03-05","conditions":"Bowel; Ischemic, Acute","enrollment":100},{"nctId":"NCT05734118","phase":"NA","title":"Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2023-08","conditions":"NEC, Atresia, Malrotation","enrollment":20},{"nctId":"NCT04712032","phase":"PHASE3","title":"Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates","status":"UNKNOWN","sponsor":"Leiden University Medical Center","startDate":"2020-07-01","conditions":"Colo-rectal Cancer, Crohn Disease, Resectable Colorectal Carcinoma","enrollment":978},{"nctId":"NCT04695964","phase":"NA","title":"Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis","status":"UNKNOWN","sponsor":"Charite University, Berlin, Germany","startDate":"2019-02-01","conditions":"Ulcerative Colitis, Colorectal Cancer, Crohn Disease","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ICG-guided bowel perfusion assessment","genericName":"ICG-guided bowel perfusion assessment","companyName":"Leiden University Medical Center","companyId":"leiden-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ICG (indocyanine green) fluorescence imaging enables real-time visualization of bowel perfusion during surgery to assess tissue viability and prevent anastomotic complications. Used for Intraoperative assessment of bowel perfusion during colorectal surgery, Prevention of anastomotic complications in gastrointestinal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}