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ICE
ICE is an intracellular caspase inhibitor that blocks apoptosis by inhibiting caspase enzymes responsible for programmed cell death.
At a glance
| Generic name | ICE |
|---|---|
| Sponsor | MedImmune LLC |
| Drug class | Caspase inhibitor |
| Target | Caspase-1 (ICE) |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
Mechanism of action
ICE (Interleukin-1β Converting Enzyme, also known as caspase-1) inhibitors work by blocking the enzymatic activity of caspases, which are proteases that execute apoptotic cell death pathways. By preventing caspase activation, these inhibitors can reduce unwanted cell death in tissues affected by inflammatory or degenerative conditions. This mechanism has been explored primarily in inflammatory and neurological disorders.
Approved indications
Common side effects
Key clinical trials
- The Effect of the Cold Arm Sling Elevation Pillow on Postoperative Anxiety and Comfort in Children (NA)
- The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease (NA)
- Methamphetamine Isomer Pharmacology in Humans (PHASE1)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Effect of Intrarectal Ice Application on Pain, Anxiety, Cortisol Levels, Development of Complications, and Hospital Readmission in Transrectal Ultrasound-Guided Prostate Biopsy (NA)
- The Effect of Intrarectal Ice Application on Pain, Anxiety, Cortisol Level, Complication Development in Transrectal Ultrasonography Guided Prostate Biopsy (NA)
- Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study (NA)
- Implementing a Contingency Management Program Addressing Methamphetamine Use For and With the People of Hawaii (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ICE CI brief — competitive landscape report
- ICE updates RSS · CI watch RSS
- MedImmune LLC portfolio CI