{"id":"ice","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":{"setId":"37dc44aa-17b2-8721-e063-6294a90a34f6","title":"MENTHOLATUM NATURAL ICE - ORIGINAL, SPF 15 ORIGINAL (DIMETHICONE, OCTINOXATE, OCTISALATE) STICK [THE MENTHOLATUM COMPANY]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ICE (Interleukin-1β Converting Enzyme, also known as caspase-1) inhibitors work by blocking the enzymatic activity of caspases, which are proteases that execute apoptotic cell death pathways. By preventing caspase activation, these inhibitors can reduce unwanted cell death in tissues affected by inflammatory or degenerative conditions. This mechanism has been explored primarily in inflammatory and neurological disorders.","oneSentence":"ICE is an intracellular caspase inhibitor that blocks apoptosis by inhibiting caspase enzymes responsible for programmed cell death.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T04:02:05.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/United_States_Immigration_and_Customs_Enforcement","title":"United States Immigration and Customs Enforcement","extract":"The United States Immigration and Customs Enforcement (ICE) is a federal law enforcement agency under the United States Department of Homeland Security. Its stated mission is to conduct criminal investigations, enforce immigration laws, preserve national security, and protect public safety. ICE was created as part of the Homeland Security Act of 2002 following the September 11 attacks. 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