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IC-Green KIT
IC-Green is a near-infrared fluorescent dye that emits light in the near-infrared spectrum when excited by appropriate wavelengths, enabling real-time visualization of tissue perfusion and vascular structures during surgical procedures.
IC-Green is a near-infrared fluorescent dye that emits light in the near-infrared spectrum when excited by appropriate wavelengths, enabling real-time visualization of tissue perfusion and vascular structures during surgical procedures. Used for Intraoperative visualization of tissue perfusion and vascular structures during reconstructive and vascular surgery, Assessment of graft viability and blood flow during surgical procedures.
At a glance
| Generic name | IC-Green KIT |
|---|---|
| Sponsor | Milton S. Hershey Medical Center |
| Drug class | Near-infrared fluorescent imaging agent |
| Target | Indocyanine green (ICG) dye — no specific receptor target; acts as a fluorophore |
| Modality | Small molecule |
| Therapeutic area | Surgery/Surgical imaging |
| Phase | Phase 3 |
Mechanism of action
Indocyanine green (ICG) is a tricarbocyanine dye that absorbs light in the near-infrared region (780–820 nm) and fluoresces at approximately 820 nm. When injected intravenously, it binds to plasma proteins and remains largely intravascular, allowing surgeons to visualize blood flow, identify vascular anatomy, and assess tissue perfusion in real time. This enables improved surgical precision and reduced complications in vascular and reconstructive procedures.
Approved indications
- Intraoperative visualization of tissue perfusion and vascular structures during reconstructive and vascular surgery
- Assessment of graft viability and blood flow during surgical procedures
Common side effects
- Anaphylaxis or anaphylactoid reaction
- Rash or urticaria
- Transient hypotension
Key clinical trials
- Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators (NA)
- High Quality Fluorescent Cholangiography (PHASE2, PHASE3)
- Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing
- SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer (PHASE3)
- Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal (NA)
- Rotator Cuff: Does the Vascularity Matter and the Role for PINPOINT (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |