{"id":"ic-green-kit","safety":{"commonSideEffects":[{"rate":null,"effect":"Anaphylaxis or anaphylactoid reaction"},{"rate":null,"effect":"Rash or urticaria"},{"rate":null,"effect":"Transient hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Indocyanine green (ICG) is a tricarbocyanine dye that absorbs light in the near-infrared region (780–820 nm) and fluoresces at approximately 820 nm. When injected intravenously, it binds to plasma proteins and remains largely intravascular, allowing surgeons to visualize blood flow, identify vascular anatomy, and assess tissue perfusion in real time. This enables improved surgical precision and reduced complications in vascular and reconstructive procedures.","oneSentence":"IC-Green is a near-infrared fluorescent dye that emits light in the near-infrared spectrum when excited by appropriate wavelengths, enabling real-time visualization of tissue perfusion and vascular structures during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:12.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative visualization of tissue perfusion and vascular structures during reconstructive and vascular surgery"},{"name":"Assessment of graft viability and blood flow during surgical procedures"}]},"trialDetails":[{"nctId":"NCT06313385","phase":"NA","title":"Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators","status":"ACTIVE_NOT_RECRUITING","sponsor":"Indonesia University","startDate":"2023-01-01","conditions":"Free Flap, Indocyanine Green, Microsurgery","enrollment":63},{"nctId":"NCT05926856","phase":"PHASE2, PHASE3","title":"High Quality Fluorescent Cholangiography","status":"COMPLETED","sponsor":"Zhujiang Hospital","startDate":"2023-08-04","conditions":"Extrahepatic Biliary Tree Injury","enrollment":168},{"nctId":"NCT02440295","phase":"","title":"Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing","status":"COMPLETED","sponsor":"Corewell Health West","startDate":"2015-05","conditions":"Wound Healing, Lower Extremity Amputation, Above Knee Amputation","enrollment":18},{"nctId":"NCT03294330","phase":"PHASE3","title":"SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer","status":"COMPLETED","sponsor":"Milton S. Hershey Medical Center","startDate":"2017-10-11","conditions":"Sentinel Lymph Node, Melanoma (Skin), Breast Cancer","enrollment":35},{"nctId":"NCT01532765","phase":"NA","title":"Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal","status":"TERMINATED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2011-09","conditions":"Epiretinal Membrane","enrollment":13},{"nctId":"NCT03001050","phase":"NA","title":"Rotator Cuff: Does the Vascularity Matter and the Role for PINPOINT","status":"WITHDRAWN","sponsor":"Nirav Amin, MD","startDate":"2017-12-20","conditions":"Rotator Cuff Tear","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IC-Green KIT","genericName":"IC-Green KIT","companyName":"Milton S. Hershey Medical Center","companyId":"milton-s-hershey-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IC-Green is a near-infrared fluorescent dye that emits light in the near-infrared spectrum when excited by appropriate wavelengths, enabling real-time visualization of tissue perfusion and vascular structures during surgical procedures. Used for Intraoperative visualization of tissue perfusion and vascular structures during reconstructive and vascular surgery, Assessment of graft viability and blood flow during surgical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}