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Ibuprofen plus Omeprazole
Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while omeprazole protects the stomach by suppressing gastric acid production.
Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while omeprazole protects the stomach by suppressing gastric acid production. Used for Osteoarthritis pain with gastric protection, Rheumatoid arthritis pain with gastric protection, Chronic pain conditions requiring NSAID therapy with reduced GI risk.
At a glance
| Generic name | Ibuprofen plus Omeprazole |
|---|---|
| Sponsor | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. |
| Drug class | NSAID plus proton pump inhibitor combination |
| Target | COX-1/COX-2 (ibuprofen); H+/K+-ATPase (omeprazole) |
| Modality | Small molecule |
| Therapeutic area | Pain management / Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase pump in gastric parietal cells, significantly reducing gastric acid secretion. This combination is designed to provide NSAID efficacy while mitigating the gastrointestinal toxicity (ulcers, bleeding) associated with chronic NSAID use.
Approved indications
- Osteoarthritis pain with gastric protection
- Rheumatoid arthritis pain with gastric protection
- Chronic pain conditions requiring NSAID therapy with reduced GI risk
Common side effects
- Headache
- Dyspepsia
- Nausea
- Abdominal pain
- Diarrhea
- Dizziness
Key clinical trials
- Evaluation of Antibiotic Administration Following Tooth Extraction (NA)
- Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery (PHASE4)
- The Effect of NSAIDs After a Rotator Cuff Repair Surgery. (PHASE4)
- Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole (PHASE4)
- YouScript IMPACT Registry
- Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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