{"id":"ibuprofen-plus-omeprazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL521","moleculeType":"Small molecule","molecularWeight":"206.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase pump in gastric parietal cells, significantly reducing gastric acid secretion. This combination is designed to provide NSAID efficacy while mitigating the gastrointestinal toxicity (ulcers, bleeding) associated with chronic NSAID use.","oneSentence":"Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while omeprazole protects the stomach by suppressing gastric acid production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:59.836Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis pain with gastric protection"},{"name":"Rheumatoid arthritis pain with gastric protection"},{"name":"Chronic pain conditions requiring NSAID therapy with reduced GI risk"}]},"trialDetails":[{"nctId":"NCT06502288","phase":"NA","title":"Evaluation of Antibiotic Administration Following Tooth Extraction","status":"NOT_YET_RECRUITING","sponsor":"Chittagong Medical College","startDate":"2025-01-01","conditions":"Tooth Extraction","enrollment":152},{"nctId":"NCT04990804","phase":"PHASE4","title":"Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-08-01","conditions":"Opioid Use, Spinal Diseases, Surgery--Complications","enrollment":8},{"nctId":"NCT02153177","phase":"PHASE4","title":"The Effect of NSAIDs After a Rotator Cuff Repair Surgery.","status":"WITHDRAWN","sponsor":"University of Chicago","startDate":"2015-01","conditions":"Rotator Cuff Tear","enrollment":""},{"nctId":"NCT00640809","phase":"PHASE4","title":"Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-10","conditions":"Bowel Diseases, Inflammatory","enrollment":408},{"nctId":"NCT02191358","phase":"","title":"YouScript IMPACT Registry","status":"COMPLETED","sponsor":"Genelex Corporation","startDate":"2014-10","conditions":"Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation","enrollment":800},{"nctId":"NCT02205489","phase":"PHASE4","title":"Management Of The Infusion-Associated Reactions In RRMS Patients Treated With LEMTRADA","status":"COMPLETED","sponsor":"Genzyme, a Sanofi Company","startDate":"2014-10","conditions":"Relapsing-remitting Multiple Sclerosis","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ibuprofen plus Omeprazole","genericName":"Ibuprofen plus Omeprazole","companyName":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","companyId":"pfizer-s-upjohn-has-merged-with-mylan-to-form-viatris-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while omeprazole protects the stomach by suppressing gastric acid production. Used for Osteoarthritis pain with gastric protection, Rheumatoid arthritis pain with gastric protection, Chronic pain conditions requiring NSAID therapy with reduced GI risk.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}