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Ibuprofen + Loratadine fixed dose
Ibuprofen + Loratadine fixed dose is a NSAID + H1-receptor antagonist combination Small molecule drug developed by Laboratorios Silanes S.A. de C.V.. It is currently in Phase 3 development for Pain and inflammation associated with allergic conditions, Headache, fever, and minor aches with concurrent allergic symptoms. Also known as: Ibu+Lora.
Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while loratadine blocks histamine H1 receptors to relieve allergic symptoms.
Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while loratadine blocks histamine H1 receptors to relieve allergic symptoms. Used for Pain and inflammation associated with allergic conditions, Headache, fever, and minor aches with concurrent allergic symptoms.
At a glance
| Generic name | Ibuprofen + Loratadine fixed dose |
|---|---|
| Also known as | Ibu+Lora |
| Sponsor | Laboratorios Silanes S.A. de C.V. |
| Drug class | NSAID + H1-receptor antagonist combination |
| Target | COX-1/COX-2 (ibuprofen); H1 histamine receptor (loratadine) |
| Modality | Small molecule |
| Therapeutic area | Pain management and Allergy/Immunology |
| Phase | Phase 3 |
Mechanism of action
This fixed-dose combination pairs a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 enzymes to reduce prostaglandin synthesis with a selective H1-receptor antagonist that prevents histamine-mediated allergic responses. The combination addresses both inflammatory pain and concurrent allergic symptoms in a single formulation.
Approved indications
- Pain and inflammation associated with allergic conditions
- Headache, fever, and minor aches with concurrent allergic symptoms
Common side effects
- Gastrointestinal upset (nausea, dyspepsia)
- Drowsiness
- Headache
- Dizziness
- Abdominal pain
Key clinical trials
- Efficacy and Safety in the Combination of Ibuprofen / Loratadine Versus Ibuprofen Versus Loratadine (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ibuprofen + Loratadine fixed dose CI brief — competitive landscape report
- Ibuprofen + Loratadine fixed dose updates RSS · CI watch RSS
- Laboratorios Silanes S.A. de C.V. portfolio CI
Frequently asked questions about Ibuprofen + Loratadine fixed dose
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Related
- Drug class: All NSAID + H1-receptor antagonist combination drugs
- Target: All drugs targeting COX-1/COX-2 (ibuprofen); H1 histamine receptor (loratadine)
- Manufacturer: Laboratorios Silanes S.A. de C.V. — full pipeline
- Therapeutic area: All drugs in Pain management and Allergy/Immunology
- Indication: Drugs for Pain and inflammation associated with allergic conditions
- Indication: Drugs for Headache, fever, and minor aches with concurrent allergic symptoms
- Also known as: Ibu+Lora
- Compare: Ibuprofen + Loratadine fixed dose vs similar drugs
- Pricing: Ibuprofen + Loratadine fixed dose cost, discount & access