{"id":"ibuprofen-loratadine-fixed-dose","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":"2-8","effect":"Drowsiness"},{"rate":"2-5","effect":"Headache"},{"rate":"1-3","effect":"Dizziness"},{"rate":"3-10","effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL521","moleculeType":"Small molecule","molecularWeight":"206.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This fixed-dose combination pairs a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 enzymes to reduce prostaglandin synthesis with a selective H1-receptor antagonist that prevents histamine-mediated allergic responses. The combination addresses both inflammatory pain and concurrent allergic symptoms in a single formulation.","oneSentence":"Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while loratadine blocks histamine H1 receptors to relieve allergic symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:22.030Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain and inflammation associated with allergic conditions"},{"name":"Headache, fever, and minor aches with concurrent allergic symptoms"}]},"trialDetails":[{"nctId":"NCT06531707","phase":"PHASE3","title":"Efficacy and Safety in the Combination of Ibuprofen / Loratadine Versus Ibuprofen Versus Loratadine","status":"RECRUITING","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-05-20","conditions":"Common Cold","enrollment":177}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ibu+Lora"],"phase":"phase_3","status":"active","brandName":"Ibuprofen + Loratadine fixed dose","genericName":"Ibuprofen + Loratadine fixed dose","companyName":"Laboratorios Silanes S.A. de C.V.","companyId":"laboratorios-silanes-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen reduces inflammation and pain by inhibiting cyclooxygenase enzymes, while loratadine blocks histamine H1 receptors to relieve allergic symptoms. Used for Pain and inflammation associated with allergic conditions, Headache, fever, and minor aches with concurrent allergic symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}