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Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole
This is a combination therapy regimen using ibuprofen (NSAID), hydrocodone/acetaminophen (opioid/analgesic), and omeprazole (proton pump inhibitor) to manage pain while protecting the gastrointestinal tract.
This is a combination therapy regimen using ibuprofen (NSAID), hydrocodone/acetaminophen (opioid/analgesic), and omeprazole (proton pump inhibitor) to manage pain while protecting the gastrointestinal tract. Used for Moderate to severe pain with gastroprotection, Chronic pain conditions requiring NSAID therapy with acid suppression.
At a glance
| Generic name | Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole |
|---|---|
| Also known as | Motrin, Advil (Ibuprofen), Norco (Hydrocodone/Acetaminophen), Prilosec (Omeprazole) |
| Sponsor | University of Chicago |
| Drug class | NSAID + opioid analgesic + proton pump inhibitor combination |
| Target | COX-1/COX-2 (ibuprofen); mu-opioid receptor (hydrocodone); H+/K+-ATPase (omeprazole) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain. Hydrocodone is an opioid agonist that binds mu-opioid receptors for analgesia, combined with acetaminophen which inhibits prostaglandin synthesis. Omeprazole suppresses gastric acid secretion by inhibiting the H+/K+-ATPase pump to reduce GI ulceration risk from chronic NSAID use.
Approved indications
- Moderate to severe pain with gastroprotection
- Chronic pain conditions requiring NSAID therapy with acid suppression
Common side effects
- Nausea
- Constipation
- Dizziness
- Headache
- Dyspepsia
Key clinical trials
- Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery (PHASE4)
- The Effect of NSAIDs After a Rotator Cuff Repair Surgery. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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