{"id":"ibuprofen-hydrocodone-acetaminophen-omeprazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dyspepsia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce inflammation and pain. Hydrocodone is an opioid agonist that binds mu-opioid receptors for analgesia, combined with acetaminophen which inhibits prostaglandin synthesis. Omeprazole suppresses gastric acid secretion by inhibiting the H+/K+-ATPase pump to reduce GI ulceration risk from chronic NSAID use.","oneSentence":"This is a combination therapy regimen using ibuprofen (NSAID), hydrocodone/acetaminophen (opioid/analgesic), and omeprazole (proton pump inhibitor) to manage pain while protecting the gastrointestinal tract.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:03.876Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain with gastroprotection"},{"name":"Chronic pain conditions requiring NSAID therapy with acid suppression"}]},"trialDetails":[{"nctId":"NCT04990804","phase":"PHASE4","title":"Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-08-01","conditions":"Opioid Use, Spinal Diseases, Surgery--Complications","enrollment":8},{"nctId":"NCT02153177","phase":"PHASE4","title":"The Effect of NSAIDs After a Rotator Cuff Repair Surgery.","status":"WITHDRAWN","sponsor":"University of Chicago","startDate":"2015-01","conditions":"Rotator Cuff Tear","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Motrin, Advil (Ibuprofen)","Norco (Hydrocodone/Acetaminophen)","Prilosec (Omeprazole)"],"phase":"marketed","status":"active","brandName":"Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole","genericName":"Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole","companyName":"University of Chicago","companyId":"university-of-chicago","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination therapy regimen using ibuprofen (NSAID), hydrocodone/acetaminophen (opioid/analgesic), and omeprazole (proton pump inhibitor) to manage pain while protecting the gastrointestinal tract. Used for Moderate to severe pain with gastroprotection, Chronic pain conditions requiring NSAID therapy with acid suppression.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}