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Ibuprofen bolus injection
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Acute pain management, Fever reduction, Postoperative pain.
At a glance
| Generic name | Ibuprofen bolus injection |
|---|---|
| Sponsor | Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Inflammation, Fever |
| Phase | FDA-approved |
Mechanism of action
As a nonsteroidal anti-inflammatory drug (NSAID), ibuprofen blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammatory responses, pain signaling, and fever regulation. The bolus injection formulation allows for rapid systemic delivery and faster onset of action compared to oral administration, making it suitable for acute pain and fever management in clinical settings.
Approved indications
- Acute pain management
- Fever reduction
- Postoperative pain
Common side effects
- Gastrointestinal bleeding or ulceration
- Renal impairment
- Cardiovascular events
- Hypersensitivity reactions
- Injection site reactions
Key clinical trials
- Para-sartorial Compartment Block in Knee Surgery (NA)
- Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia (PHASE4)
- The Application of Thoracic Epidural Analgesia in Patients With Acute Pancreatitis (NA)
- Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery (NA)
- Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery (NA)
- Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098) (PHASE3)
- The Efficacy Of Ultrasound-Guided Adductor Canal Block for Arthroscopic Knee Surgery (NA)
- Erector Spinae Plane Block and Modified-Thoracolumbar Interfascial Plane Block Following Lumbar Spinal Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |