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The bolus injection formulation allows for rapid systemic delivery and faster onset of action compared to oral administration, making it suitable for acute pain and fever management in clinical settings.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:00.310Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management"},{"name":"Fever reduction"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT05566561","phase":"NA","title":"Para-sartorial Compartment Block in Knee Surgery","status":"COMPLETED","sponsor":"Medipol University","startDate":"2022-10-19","conditions":"Knee Osteoarthritis, Knee Injuries, Knee Disease","enrollment":60},{"nctId":"NCT07070050","phase":"PHASE4","title":"Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia","status":"RECRUITING","sponsor":"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology","startDate":"2025-05-05","conditions":"Analgesic Drugs, Analgesic, Nonopioid, Analgesic Efficacy","enrollment":100},{"nctId":"NCT06327230","phase":"NA","title":"The Application of Thoracic Epidural Analgesia in Patients With Acute Pancreatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sir Run Run Shaw Hospital","startDate":"2024-03-01","conditions":"Acute Pancreatitis","enrollment":88},{"nctId":"NCT04189341","phase":"NA","title":"Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery","status":"WITHDRAWN","sponsor":"Medipol University","startDate":"2020-01-10","conditions":"Lumbar Spine Instability, Lumbar Spinal Stenosis, Lumbar Disc Disease","enrollment":""},{"nctId":"NCT04189640","phase":"NA","title":"Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery","status":"WITHDRAWN","sponsor":"Medipol University","startDate":"2020-01-10","conditions":"Knee Osteoarthritis, Knee Arthropathy, Knee Pain Chronic","enrollment":""},{"nctId":"NCT00820027","phase":"PHASE3","title":"Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2008-12-15","conditions":"Pain, Postoperative","enrollment":776},{"nctId":"NCT04010916","phase":"NA","title":"The Efficacy Of Ultrasound-Guided Adductor Canal Block for Arthroscopic Knee Surgery","status":"COMPLETED","sponsor":"Medipol University","startDate":"2019-07-01","conditions":"Knee Arthropathy","enrollment":90},{"nctId":"NCT04073095","phase":"NA","title":"Erector Spinae Plane Block and Modified-Thoracolumbar Interfascial Plane Block Following Lumbar Spinal Surgery","status":"COMPLETED","sponsor":"Medipol University","startDate":"2019-09-13","conditions":"Lumbar Disc Herniation","enrollment":90},{"nctId":"NCT03854773","phase":"NA","title":"Erector Spinae Plane Block and Thoracal Paravertebral Block Following Video Assisted Thoracic Surgery","status":"COMPLETED","sponsor":"Medipol University","startDate":"2019-03-01","conditions":"Lung Diseases","enrollment":90},{"nctId":"NCT03068260","phase":"PHASE4","title":"Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2017-03-15","conditions":"Postoperative Pain","enrollment":72}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ibuprofen bolus injection","genericName":"Ibuprofen bolus injection","companyName":"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology","companyId":"federal-research-and-clinical-centre-of-intensive-care-medicine-and-rehabilitolo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen is a small molecule that acts as a cyclooxygenase inhibitor, belonging to the drug class of inhibitors. It is used to treat pain, including postoperative pain, as indicated by clinical trials for conditions such as postoperative pain and analgesic efficacy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}