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Hydroxyzine Hydrochloride (HYDROXYZINE)

Pfizer · FDA-approved approved Small molecule Quality 49/100

Hydroxyzine Hydrochloride (HYDROXYZINE) is a small molecule antihistamine that targets the histamine H1 receptor. Originally developed by Pfizer in 1956, it is currently owned by the same company and is off-patent, with 13 generic manufacturers. This medication is used to treat various allergic conditions, including allergic conjunctivitis, rhinitis, and urticaria. Hydroxyzine works by blocking the action of histamine, a chemical released during allergic reactions, thereby reducing symptoms such as itching and nasal discharge. As an off-patent medication, it is widely available in generic forms.

At a glance

Generic nameHYDROXYZINE
SponsorPfizer
Drug classAntihistamine
TargetHistamine H1 receptor
ModalitySmall molecule
Therapeutic areaImmunology
PhaseFDA-approved
First approval1956

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
FDA labelMechanism, indications, dosing, boxed warnings, drug interactions
ClinicalTrials.govTrial enrolment, design, endpoints, results

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