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hydroxyethl starch
Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and fluid retention in the vascular space.
Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and fluid retention in the vascular space. Used for Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma.
At a glance
| Generic name | hydroxyethl starch |
|---|---|
| Also known as | Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection |
| Sponsor | China International Neuroscience Institution |
| Drug class | Synthetic colloid / Volume expander |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
HES is a glucose polymer derivative that functions as a volume expander used in fluid resuscitation. It remains in the intravascular compartment longer than crystalloid solutions, providing sustained hemodynamic support. The molecule's size and degree of substitution determine its pharmacokinetic properties and duration of action.
Approved indications
- Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma
Common side effects
- Acute kidney injury
- Coagulopathy / increased bleeding
- Hyperchloremic acidosis
- Anaphylaxis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |