{"id":"hydroxyethl-starch","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HES is a glucose polymer derivative that functions as a volume expander used in fluid resuscitation. It remains in the intravascular compartment longer than crystalloid solutions, providing sustained hemodynamic support. The molecule's size and degree of substitution determine its pharmacokinetic properties and duration of action.","oneSentence":"Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and fluid retention in the vascular space.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:02.860Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma"}]},"trialDetails":[{"nctId":"NCT04432675","phase":"PHASE4","title":"Effects of Crystal Solution and Colloid Solution on Mother and Fetus","status":"COMPLETED","sponsor":"China International Neuroscience Institution","startDate":"2022-01-30","conditions":"Cesarean Section, Spinal Anesthesia, Parturition","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection"],"phase":"marketed","status":"active","brandName":"hydroxyethl starch","genericName":"hydroxyethl starch","companyName":"China International Neuroscience Institution","companyId":"china-international-neuroscience-institution","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and fluid retention in the vascular space. Used for Acute blood loss and hypovolemia requiring volume replacement during surgery or trauma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}