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Hydroquinone cream
Hydroquinone cream is a Depigmenting agent Small molecule drug developed by National Skin Centre. It is currently FDA-approved for Hyperpigmentation disorders (melasma, post-inflammatory hyperpigmentation, lentigines), Uneven skin tone and discoloration. Also known as: Claripel, Lustra.
Hydroquinone inhibits melanin production by suppressing tyrosinase activity in melanocytes.
Hydroquinone inhibits melanin production by suppressing tyrosinase activity in melanocytes. Used for Hyperpigmentation disorders (melasma, post-inflammatory hyperpigmentation, lentigines), Uneven skin tone and discoloration.
At a glance
| Generic name | Hydroquinone cream |
|---|---|
| Also known as | Claripel, Lustra |
| Sponsor | National Skin Centre |
| Drug class | Depigmenting agent |
| Target | Tyrosinase |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Hydroquinone is a depigmenting agent that works by inhibiting the enzyme tyrosinase, which catalyzes the conversion of tyrosine to melanin. This reduces melanin synthesis and can gradually lighten hyperpigmented skin lesions. It may also increase the degradation of existing melanin and inhibit the transfer of melanosomes to keratinocytes.
Approved indications
- Hyperpigmentation disorders (melasma, post-inflammatory hyperpigmentation, lentigines)
- Uneven skin tone and discoloration
Common side effects
- Contact dermatitis
- Irritation and erythema
- Dryness and scaling
- Ochronosis (with prolonged use)
Key clinical trials
- Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi (NA)
- Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma (NA)
- Prospective Evaluation of Topical Almond Oil vs Hydroquinone (PHASE4)
- COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS (NA)
- Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES (NA)
- Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study (PHASE2)
- EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA (NA)
- Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of Melasma (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hydroquinone cream CI brief — competitive landscape report
- Hydroquinone cream updates RSS · CI watch RSS
- National Skin Centre portfolio CI
Frequently asked questions about Hydroquinone cream
What is Hydroquinone cream?
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Is Hydroquinone cream also known as anything else?
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Related
- Drug class: All Depigmenting agent drugs
- Target: All drugs targeting Tyrosinase
- Manufacturer: National Skin Centre — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Hyperpigmentation disorders (melasma, post-inflammatory hyperpigmentation, lentigines)
- Indication: Drugs for Uneven skin tone and discoloration
- Also known as: Claripel, Lustra
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing