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High Volume Simethicone
Simethicone is an antifoaming agent that reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.
Simethicone is an antifoaming agent that reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily. Used for Bloating and abdominal distension, Flatulence and gas-related discomfort, Post-procedure gastrointestinal gas relief.
At a glance
| Generic name | High Volume Simethicone |
|---|---|
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Drug class | Antifoaming agent |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Simethicone works by decreasing the surface tension of gas bubbles in the stomach and intestines, causing smaller bubbles to merge into larger ones that can be more readily eliminated through belching or flatulence. This reduces bloating, abdominal discomfort, and pressure sensations associated with trapped gas. The high-volume formulation delivers increased concentrations of the active agent to provide enhanced symptomatic relief.
Approved indications
- Bloating and abdominal distension
- Flatulence and gas-related discomfort
- Post-procedure gastrointestinal gas relief
Common side effects
- Constipation
- Diarrhea
- Nausea
Key clinical trials
- Evaluate the Detection of Retained Gastric Contents and Assess Safety Using the Flower Capsule Endoscopy in Healthy Individuals and GLP-1 Receptor Agonist Users (NA)
- Low-volume vs High-volume Polyethylene Glycol Based Bowel Preparation for Colonoscopy in People Receiving Hemodialysis (PHASE4)
- High Volume Simethicone VCE Clinical Trial (PHASE4)
- Small Bowel Cleansing for Capsule Endoscopy in Pediatric Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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