{"id":"high-volume-simethicone","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL4297192","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Simethicone works by decreasing the surface tension of gas bubbles in the stomach and intestines, causing smaller bubbles to merge into larger ones that can be more readily eliminated through belching or flatulence. This reduces bloating, abdominal discomfort, and pressure sensations associated with trapped gas. The high-volume formulation delivers increased concentrations of the active agent to provide enhanced symptomatic relief.","oneSentence":"Simethicone is an antifoaming agent that reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:26.336Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bloating and abdominal distension"},{"name":"Flatulence and gas-related discomfort"},{"name":"Post-procedure gastrointestinal gas relief"}]},"trialDetails":[{"nctId":"NCT06927401","phase":"NA","title":"Evaluate the Detection of Retained Gastric Contents and Assess Safety Using the Flower Capsule Endoscopy in Healthy Individuals and GLP-1 Receptor Agonist Users","status":"NOT_YET_RECRUITING","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2025-04-08","conditions":"Endoscopy, Digestive System, GLP1-R-related Disease","enrollment":36},{"nctId":"NCT04709770","phase":"PHASE4","title":"Low-volume vs High-volume Polyethylene Glycol Based Bowel Preparation for Colonoscopy in People Receiving Hemodialysis","status":"UNKNOWN","sponsor":"Alfredo Di Leo","startDate":"2021-02-01","conditions":"Chronic Kidney Diseases, Colon Polyp, Dialysis; Complications","enrollment":264},{"nctId":"NCT02334631","phase":"PHASE4","title":"High Volume Simethicone VCE Clinical Trial","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2017-01","conditions":"Small Bowel Diseases","enrollment":159},{"nctId":"NCT01783782","phase":"PHASE4","title":"Small Bowel Cleansing for Capsule Endoscopy in Pediatric Patients","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2005-11","conditions":"Capsule Endoscopy","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"High Volume Simethicone","genericName":"High Volume Simethicone","companyName":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","companyId":"london-health-sciences-centre-research-institute-or-lawson-research-institute-of","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Simethicone is an antifoaming agent that reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily. Used for Bloating and abdominal distension, Flatulence and gas-related discomfort, Post-procedure gastrointestinal gas relief.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}