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high bile acid binding blenderized diet
A specialized blenderized diet formulation that binds bile acids in the gastrointestinal tract to reduce their reabsorption and lower circulating bile acid levels.
A specialized blenderized diet formulation that binds bile acids in the gastrointestinal tract to reduce their reabsorption and lower circulating bile acid levels. Used for Progressive familial intrahepatic cholestasis (PFIC), Bile acid malabsorption disorders.
At a glance
| Generic name | high bile acid binding blenderized diet |
|---|---|
| Sponsor | Boston Children's Hospital |
| Drug class | Dietary intervention / Bile acid sequestrant |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Hepatology |
| Phase | FDA-approved |
Mechanism of action
This dietary intervention increases bile acid sequestration in the intestinal lumen, preventing enterohepatic circulation and promoting fecal excretion of bile acids. By reducing systemic bile acid levels, the diet aims to ameliorate symptoms and complications associated with bile acid malabsorption or elevated bile acid metabolism. This is a non-pharmacological approach used primarily in pediatric patients with specific metabolic or hepatic conditions.
Approved indications
- Progressive familial intrahepatic cholestasis (PFIC)
- Bile acid malabsorption disorders
Common side effects
- Gastrointestinal distress
- Constipation
- Palatability issues / poor compliance
Key clinical trials
- The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 3)
- The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 2) (PHASE4)
- The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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