{"id":"high-bile-acid-binding-blenderized-diet","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal distress"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Palatability issues / poor compliance"}]},"_chembl":{"chemblId":"CHEMBL1258080","moleculeType":"Small molecule","molecularWeight":"434.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This dietary intervention increases bile acid sequestration in the intestinal lumen, preventing enterohepatic circulation and promoting fecal excretion of bile acids. By reducing systemic bile acid levels, the diet aims to ameliorate symptoms and complications associated with bile acid malabsorption or elevated bile acid metabolism. This is a non-pharmacological approach used primarily in pediatric patients with specific metabolic or hepatic conditions.","oneSentence":"A specialized blenderized diet formulation that binds bile acids in the gastrointestinal tract to reduce their reabsorption and lower circulating bile acid levels.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:47:39.038Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Progressive familial intrahepatic cholestasis (PFIC)"},{"name":"Bile acid malabsorption disorders"}]},"trialDetails":[{"nctId":"NCT06913621","phase":"","title":"The Use of High Bile-Binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 3)","status":"NOT_YET_RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2026-07","conditions":"Feeding Difficulties, Gastrostomy, Aspiration","enrollment":138},{"nctId":"NCT07303868","phase":"PHASE4","title":"The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 2)","status":"NOT_YET_RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2026-07","conditions":"Feeding Difficulties, Gastrostomy, Aspiration","enrollment":66},{"nctId":"NCT07303738","phase":"PHASE4","title":"The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1)","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2025-12-01","conditions":"Feeding Difficulties, Aspiration, Gastrostomy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"high bile acid binding blenderized diet","genericName":"high bile acid binding blenderized diet","companyName":"Boston Children's Hospital","companyId":"boston-children-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A specialized blenderized diet formulation that binds bile acids in the gastrointestinal tract to reduce their reabsorption and lower circulating bile acid levels. Used for Progressive familial intrahepatic cholestasis (PFIC), Bile acid malabsorption disorders.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}