Last reviewed · How we verify
HF medication
Blocks the action of aldosterone
Blocks the action of aldosterone Used for Hypertension, Heart failure.
At a glance
| Generic name | HF medication |
|---|---|
| Sponsor | Bayer |
| Drug class | Mineralocorticoid receptor antagonist |
| Target | Mineralocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
This is achieved through the inhibition of the mineralocorticoid receptor, which is responsible for the regulation of electrolyte balance and blood pressure.
Approved indications
- Hypertension
- Heart failure
Common side effects
- Hyperkalemia
- Fatigue
- Dizziness
Key clinical trials
- Medication Withdrawal in Stable HF With Improved LVEF (PHASE2, PHASE3)
- Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure (NA)
- Mind Your Heart-II (NA)
- A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) (PHASE2)
- RESPONDER-HF Trial (NA)
- HF-TRACK: A UK RCT of an Passive Heart Failure Monitoring and Tracking Device (NA)
- Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan (PHASE1, PHASE2)
- Effect of the Home-based Digital-assisted Dyadic Tai Chi (HDTC) Training Program Among Sedentary Individuals With HF and Their Caregivers: a Randomized Controlled Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |