Last reviewed 2026-04-22 · How we verify

HES 130/0.42 + electrolyte solution

HES 130/0.42 is a synthetic colloid that expands intravascular volume and maintains oncotic pressure to restore and maintain circulating blood volume in hypovolemic patients.

HES 130/0.42 is a synthetic colloid that expands intravascular volume and maintains oncotic pressure to restore and maintain circulating blood volume in hypovolemic patients. Used for Acute hypovolemia and restoration of circulating blood volume in surgical and trauma patients, Perioperative fluid management in patients requiring volume replacement.

At a glance

Mechanism of action

Hydroxyethyl starch (HES) 130/0.42 consists of starch molecules with a molecular weight of 130 kDa and degree of substitution of 0.42, which remain in the intravascular space longer than crystalloids. When combined with electrolyte solution, it provides both colloid osmotic support and electrolyte balance to treat acute hypovolemia and maintain hemodynamic stability during surgery or critical illness.

Approved indications

• Acute hypovolemia and restoration of circulating blood volume in surgical and trauma patients
• Perioperative fluid management in patients requiring volume replacement

Common side effects

• Hyperchloremic acidosis
• Acute kidney injury
• Coagulopathy / increased bleeding
• Anaphylactic reactions
• Hyperamylasemia

Key clinical trials

• Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions (PHASE4)
• Use of Two Modern Hydroxyethyl Starch Solutions in Major Urological Procedures (PHASE4)
• Comparison of HES 130 in Balanced and in Unbalanced Solution (PHASE3)
• Tetraspan 6 Percent (%) Combined With Sterofundin ISO Versus Albumin 5 Percent (%) Combined With Sodium Chloride (NaCL) (PHASE4)

Primary sources

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