{"id":"hes-130-0-42-electrolyte-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":"rare","effect":"Anaphylactic reactions"},{"rate":null,"effect":"Hyperamylasemia"}]},"_chembl":{"chemblId":"CHEMBL2108701","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxyethyl starch (HES) 130/0.42 consists of starch molecules with a molecular weight of 130 kDa and degree of substitution of 0.42, which remain in the intravascular space longer than crystalloids. When combined with electrolyte solution, it provides both colloid osmotic support and electrolyte balance to treat acute hypovolemia and maintain hemodynamic stability during surgery or critical illness.","oneSentence":"HES 130/0.42 is a synthetic colloid that expands intravascular volume and maintains oncotic pressure to restore and maintain circulating blood volume in hypovolemic patients.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:34.171Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypovolemia and restoration of circulating blood volume in surgical and trauma patients"},{"name":"Perioperative fluid management in patients requiring volume replacement"}]},"trialDetails":[{"nctId":"NCT01117649","phase":"PHASE4","title":"Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions","status":"COMPLETED","sponsor":"B. Braun Melsungen AG","startDate":"2010-05","conditions":"Plasma Volume Replacement, Surgery of the Pancreatic Head","enrollment":63},{"nctId":"NCT01670604","phase":"PHASE4","title":"Use of Two Modern Hydroxyethyl Starch Solutions in Major Urological Procedures","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2012-01","conditions":"Urologic Surgical Procedures","enrollment":40},{"nctId":"NCT01301469","phase":"PHASE3","title":"Comparison of HES 130 in Balanced and in Unbalanced Solution","status":"COMPLETED","sponsor":"B. Braun Melsungen AG","startDate":"2011-02","conditions":"Decreased and Nonspecific Blood Pressure Disorders and Shock","enrollment":240},{"nctId":"NCT00936247","phase":"PHASE4","title":"Tetraspan 6 Percent (%) Combined With Sterofundin ISO Versus Albumin 5 Percent (%) Combined With Sodium Chloride (NaCL)","status":"TERMINATED","sponsor":"B. Braun Melsungen AG","startDate":"2009-11","conditions":"Renal Insufficiency","enrollment":2}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"HES 130/0.42 + electrolyte solution","genericName":"HES 130/0.42 + electrolyte solution","companyName":"B. Braun Melsungen AG","companyId":"b-braun-melsungen-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HES 130/0.42 is a synthetic colloid that expands intravascular volume and maintains oncotic pressure to restore and maintain circulating blood volume in hypovolemic patients. Used for Acute hypovolemia and restoration of circulating blood volume in surgical and trauma patients, Perioperative fluid management in patients requiring volume replacement.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}