Last reviewed · How we verify
hepatitis A vaccine, DTaP, PCV10
hepatitis A vaccine, DTaP, PCV10 is a combination vaccine Biologic drug developed by KEMRI-Wellcome Trust Collaborative Research Program. It is currently FDA-approved for Prevention of hepatitis A, Prevention of diphtheria, Prevention of tetanus. Also known as: Synflorix.
This is a combination vaccine that stimulates the immune system to produce antibodies against hepatitis A virus, diphtheria, tetanus, pertussis, and pneumococcal pathogens.
This is a combination vaccine that stimulates the immune system to produce antibodies against hepatitis A virus, diphtheria, tetanus, pertussis, and pneumococcal pathogens. Used for Prevention of hepatitis A, Prevention of diphtheria, Prevention of tetanus.
At a glance
| Generic name | hepatitis A vaccine, DTaP, PCV10 |
|---|---|
| Also known as | Synflorix |
| Sponsor | KEMRI-Wellcome Trust Collaborative Research Program |
| Drug class | combination vaccine |
| Modality | Biologic |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
Mechanism of action
The vaccine contains inactivated hepatitis A virus antigen, toxoids for diphtheria and tetanus, acellular pertussis components, and pneumococcal polysaccharide conjugates. These antigens trigger both humoral and cellular immune responses, leading to the production of protective antibodies and memory B cells against these pathogens. Upon exposure to the actual pathogens, the primed immune system rapidly produces antibodies to neutralize or eliminate the infectious agents.
Approved indications
- Prevention of hepatitis A
- Prevention of diphtheria
- Prevention of tetanus
- Prevention of pertussis (whooping cough)
- Prevention of pneumococcal disease (PCV10 serotypes)
Common side effects
- Injection site pain, redness, or swelling
- Fever
- Irritability or fussiness
- Drowsiness
- Loss of appetite
Key clinical trials
- Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe (PHASE3)
- Safety and Immunogenicity Study of a Booster Dose of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine. (PHASE3)
- Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine (PHASE3)
- Study to Evaluate the Safety and Immunogenicity of a 10-valent Pneumococcal Conjugate Vaccine in Preterm Infants (PHASE3)
- Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose (PHASE3)
- Safety & Immunogenicity Study of 10-Valent Pneumococcal Conjugate Vaccine When Administered as a 2-Dose Schedule (PHASE3)
- PCV10 Reactogenicity and Immunogenicity Study - Malindi (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- hepatitis A vaccine, DTaP, PCV10 CI brief — competitive landscape report
- hepatitis A vaccine, DTaP, PCV10 updates RSS · CI watch RSS
- KEMRI-Wellcome Trust Collaborative Research Program portfolio CI
Frequently asked questions about hepatitis A vaccine, DTaP, PCV10
What is hepatitis A vaccine, DTaP, PCV10?
How does hepatitis A vaccine, DTaP, PCV10 work?
What is hepatitis A vaccine, DTaP, PCV10 used for?
Who makes hepatitis A vaccine, DTaP, PCV10?
Is hepatitis A vaccine, DTaP, PCV10 also known as anything else?
What drug class is hepatitis A vaccine, DTaP, PCV10 in?
What development phase is hepatitis A vaccine, DTaP, PCV10 in?
What are the side effects of hepatitis A vaccine, DTaP, PCV10?
Related
- Drug class: All combination vaccine drugs
- Manufacturer: KEMRI-Wellcome Trust Collaborative Research Program — full pipeline
- Therapeutic area: All drugs in Immunology
- Indication: Drugs for Prevention of hepatitis A
- Indication: Drugs for Prevention of diphtheria
- Indication: Drugs for Prevention of tetanus
- Also known as: Synflorix
- Compare: hepatitis A vaccine, DTaP, PCV10 vs similar drugs
- Pricing: hepatitis A vaccine, DTaP, PCV10 cost, discount & access