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Hemoporfin PDT
Hemoporfin is a photosensitizer that generates reactive oxygen species upon light activation to destroy tumor cells in photodynamic therapy.
Hemoporfin is a photosensitizer that generates reactive oxygen species upon light activation to destroy tumor cells in photodynamic therapy. Used for Esophageal cancer, Gastric cancer, Bladder cancer.
At a glance
| Generic name | Hemoporfin PDT |
|---|---|
| Sponsor | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. |
| Drug class | Photosensitizer |
| Target | Porphyrin-based photosensitizer (non-receptor mediated) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Mechanism of action
Hemoporfin is a hematoporphyrin derivative that accumulates in tumor tissue. When activated by red light at specific wavelengths, it undergoes photochemical reactions that produce singlet oxygen and free radicals, causing direct tumor cell death and vascular damage. This mechanism enables selective destruction of malignant tissue while minimizing damage to surrounding healthy tissue.
Approved indications
- Esophageal cancer
- Gastric cancer
- Bladder cancer
- Endobronchial tumors
Common side effects
- Photosensitivity
- Esophageal stricture
- Chest pain
- Dysphagia
Key clinical trials
- A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT (PHASE2)
- Enhanced Efficacy Through Optimization of Hemoporfin-Photodynamic Therapy Parameters in Port-Wine Stains (NA)
- Exacerbation of Erythema Following PDT in Patients With Probable Capillary Malformation-Arteriovenous Malformation Syndrome: Retrospective Analysis of Ultrasound and Clinical Characteristics.
- Retrospective Cohort Study on the Impact of PDL Treatment History on the Efficacy of HMME-PDT in Treating PWS Children
- Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain (PHASE4)
- A Pilot Study of Hemoporfin PDT in Children(2-7 Years Old) With Port-wine Stain (PHASE4)
- Effect of Pulsed Dye Laser on Photodynamic Therapy of Port-Wine Stains (NA)
- A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |