{"id":"hemoporfin-pdt","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Esophageal stricture"},{"rate":null,"effect":"Chest pain"},{"rate":null,"effect":"Dysphagia"}]},"_chembl":{"chemblId":"CHEMBL5595869","moleculeType":null,"molecularWeight":"458.64"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hemoporfin is a hematoporphyrin derivative that accumulates in tumor tissue. When activated by red light at specific wavelengths, it undergoes photochemical reactions that produce singlet oxygen and free radicals, causing direct tumor cell death and vascular damage. This mechanism enables selective destruction of malignant tissue while minimizing damage to surrounding healthy tissue.","oneSentence":"Hemoporfin is a photosensitizer that generates reactive oxygen species upon light activation to destroy tumor cells in photodynamic therapy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:47:29.766Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Esophageal cancer"},{"name":"Gastric cancer"},{"name":"Bladder cancer"},{"name":"Endobronchial tumors"}]},"trialDetails":[{"nctId":"NCT05171894","phase":"PHASE2","title":"A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT","status":"RECRUITING","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2024-09-21","conditions":"Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus","enrollment":84},{"nctId":"NCT07353385","phase":"NA","title":"Enhanced Efficacy Through Optimization of Hemoporfin-Photodynamic Therapy Parameters in Port-Wine Stains","status":"COMPLETED","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2024-07-01","conditions":"Port Wine Stains","enrollment":33},{"nctId":"NCT06985563","phase":"","title":"Exacerbation of Erythema Following PDT in Patients With Probable Capillary Malformation-Arteriovenous Malformation Syndrome: Retrospective Analysis of Ultrasound and Clinical Characteristics.","status":"COMPLETED","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2024-03-01","conditions":"Probable Capillary Malformation-Arteriovenous Malformation Syndrome","enrollment":16},{"nctId":"NCT06875492","phase":"","title":"Retrospective Cohort Study on the Impact of PDL Treatment History on the Efficacy of HMME-PDT in Treating PWS Children","status":"COMPLETED","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2024-04-01","conditions":"Port-Wine Stain","enrollment":273},{"nctId":"NCT03181984","phase":"PHASE4","title":"Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2017-08-31","conditions":"Port-Wine Stain","enrollment":501},{"nctId":"NCT04106258","phase":"PHASE4","title":"A Pilot Study of Hemoporfin PDT in Children(2-7 Years Old) With Port-wine Stain","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2020-05-27","conditions":"Port-wine Stain","enrollment":40},{"nctId":"NCT04536740","phase":"NA","title":"Effect of Pulsed Dye Laser on Photodynamic Therapy of Port-Wine Stains","status":"UNKNOWN","sponsor":"Gang Ma","startDate":"2020-10-01","conditions":"Port-Wine Stain","enrollment":68},{"nctId":"NCT03125057","phase":"PHASE4","title":"A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2017-08-02","conditions":"Port-wine Stain","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Hemoporfin PDT","genericName":"Hemoporfin PDT","companyName":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","companyId":"shanghai-fudan-zhangjiang-bio-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hemoporfin is a photosensitizer that generates reactive oxygen species upon light activation to destroy tumor cells in photodynamic therapy. Used for Esophageal cancer, Gastric cancer, Bladder cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}