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Heavy Bupivacaine
Heavy bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Heavy bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Spinal anesthesia for surgical procedures, Local infiltration anesthesia.
At a glance
| Generic name | Heavy Bupivacaine |
|---|---|
| Also known as | marcaine heavy |
| Sponsor | Diskapi Yildirim Beyazit Education and Research Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and nerve impulse transmission. The 'heavy' formulation refers to bupivacaine combined with dextrose (hyperbaric solution), which increases density and allows for controlled spinal distribution during intrathecal administration. This formulation is used primarily for spinal anesthesia in surgical procedures.
Approved indications
- Spinal anesthesia for surgical procedures
- Local infiltration anesthesia
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Neurological toxicity (at high doses)
- Cardiac arrhythmias (systemic toxicity)
Key clinical trials
- The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Surgery on the Heart (NA)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Haemodynamic Effects and Complications of Continuous Versus Single-shot Spinal Anaesthesia for HIP Fracture Surgery (PHASE4)
- Post Spinal Hemodynamic Changes in Aortic Stenosis and Mitral Regurgitation by VIS Index and Echocardiography
- Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and Fentanyl (PHASE4)
- Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Heavy Bupivacaine CI brief — competitive landscape report
- Heavy Bupivacaine updates RSS · CI watch RSS
- Diskapi Yildirim Beyazit Education and Research Hospital portfolio CI