Last reviewed 2026-04-23 · How we verify

Half dose CBD

Half dose CBD is a reduced form of cannabidiol that interacts with the endocannabinoid system to modulate various physiological processes.

Half dose CBD is a reduced form of cannabidiol that interacts with the endocannabinoid system to modulate various physiological processes. Used for Chronic pain management, Anxiety disorders.

At a glance

Mechanism of action

By reducing the dose, it aims to minimize side effects while still engaging with cannabinoid receptors CB1 and CB2, which can influence pain, inflammation, and other functions.

Approved indications

• Chronic pain management
• Anxiety disorders

Common side effects

• Drowsiness
• Dry mouth

Key clinical trials

• Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial (PHASE3)
• Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH (PHASE2)
• The Effects of Cannabidiol on the Driving Performance of Healthy Adults by Dose and Sex (PHASE1)
• Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype (PHASE2)
• Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy (PHASE2)
• Determination of Cannabinoid and Cannabinoid Metabolite Levels in Healthy Volunteers (EARLY_PHASE1)
• A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults (PHASE3)
• A Dose-ranging Pharmacokinetics and Safety Study of GWP42003-P in Children With Dravet Syndrome (GWPCARE1) (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.