Last reviewed · How we verify
Group C : Saline + propofol group
Propofol is an intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system, while saline serves as a vehicle for administration.
Propofol is an intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system, while saline serves as a vehicle for administration. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units.
At a glance
| Generic name | Group C : Saline + propofol group |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Intravenous anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization, resulting in sedation and anesthesia. Saline is a physiological carrier solution used to dilute and deliver propofol intravenously. This combination is used for induction and maintenance of anesthesia in clinical settings.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy (NA)
- Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery (NA)
- The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery (NA)
- The Effect of Methylprednisolone on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group (PHASE4)
- Female Sexual Dysfunction Assessment and Managment of Vaginismus (PHASE2, PHASE3)
- Comparing the Synergistic Effect of Caudal Dexmedetomidine and Propofol Versus Caudal Dexmedetomidine Only or Propofol Only in Prevention of Sevoflurane Related Emergence Agitation in Pediatric Patients Undergoing Congenital Inguinal Hernia Repair (PHASE4)
- Effect of Propofol Administration Time on the Incidence and Severity of Intrathecal Morphine-induced Pruritus in Parturient Undergoing Elective Cesarean Delivaries (PHASE4)
- The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: